Non-receptor tyrosine-protein kinase TNK1 (TNK1) is a 666-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13470.
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The mean pLDDT of this model is 72.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 40% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction
Interacts with the SH3 domain of PLCG1 via its Pro-rich domain
Cytoplasm, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7TDY | X-ray | 1.53 Å | A=590-666 |
| 7TCY | X-ray | 1.54 Å | A/B=589-666 |
| 7T8J | X-ray | 1.89 Å | A=590-666 |
| 9ZVU | X-ray | 1.96 Å | A/B=590-666 |
| 9NGE | X-ray | 2.02 Å | A/B=590-666 |
| 9Z2L | X-ray | 2.02 Å | A/B=590-666 |
| 7U4Z | X-ray | 2.03 Å | A=590-666 |
| 7U4W | X-ray | 2.1 Å | A=590-666 |
| 9O0H | X-ray | 2.24 Å | B=590-666 |
| 9CPL | X-ray | 2.4 Å | A=590-666 |
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