Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) is a 2472-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13813.
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The mean pLDDT of this model is 76.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 4% |
| 70 to 90 | Confident: backbone generally right | 78% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane
Like erythrocyte spectrin, the spectrin-like proteins are capable of forming dimers which can further associate to tetramers. Interacts (via C-terminal spectrin repeats) with TRPC4. Interacts with CALM and EMD. Interacts with isoform 1 of ACP1. Identified in a complex with ACTN4, CASK, IQGAP1, MAGI2, NPHS1 and SPTBN1. Interacts with SHANK3 (via ANK repeats). Interacts with CLN3; this interaction…
Cytoplasm, cytoskeleton, Cytoplasm, cell cortex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6ZEH | X-ray | 1.3 Å | A/B=1025-1039 |
| 5FWC | X-ray | 1.4 Å | A=965-1022 |
| 5FWB | X-ray | 1.5 Å | A=965-1023 |
| 5FW9 | X-ray | 1.55 Å | A=965-1025 |
| 3F31 | X-ray | 2.3 Å | A/B=1-147 |
| 3FB2 | X-ray | 2.3 Å | A/B=1337-1544 |
| 2FOT | X-ray | 2.45 Å | C=1172-1211 |
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