Core-binding factor subunit beta (CBFB) is a 182-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13951.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription…
Heterodimer with RUNX1, RUNX2 and RUNX3. Interacts with COPRS. Found in a complex with PRMT5 and RUNX1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8J62 | EM | 2.5 Å | D/F/H/J=1-156 |
| 1E50 | X-ray | 2.6 Å | B/D/F/H=2-135 |
| 1H9D | X-ray | 2.6 Å | B/D=2-135 |
| 8CX0 | EM | 2.7 Å | C=1-182 |
| 8H0I | EM | 2.8 Å | D/F/H/J=1-156 |
| 6P59 | X-ray | 2.94 Å | A/C=1-165 |
| 8CX2 | EM | 3.2 Å | C/H=1-182 |
| 8FVI | EM | 3.24 Å | 0=1-157 |
| 4N9F | X-ray | 3.3 Å | 0/6/F/L/N/R/a/c/i/k/o/u=1-170 |
| 8CX1 | EM | 3.3 Å | C/H=1-182 |
| 8FVJ | EM | 3.54 Å | 0/5=1-157 |
| 8E40 | EM | 3.57 Å | C=1-157 |
| 8SZK | EM | 3.58 Å | C=1-170 |
| 9E93 | EM | 3.58 Å | o/s=1-170 |
| 6NIL | EM | 3.9 Å | B/E/H/K=1-151 |
| 9E9V | EM | 4.0 Å | o/s=1-170 |
| 6VGD | X-ray | 4.2 Å | G=1-142 |
| 6VGE | X-ray | 4.25 Å | G=1-142 |
| 6VGG | X-ray | 4.31 Å | G=1-142 |
| 1CL3 | NMR | A=4-141 |
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