Caprin-1 (CAPRIN1) is a 709-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14444.
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The mean pLDDT of this model is 57.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 62% |
What pLDDT means and how to read it
mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:17210633, PubMed:31439799, PubMed:35979925). Plays an essential role in cytoplasmic stress granule formation (PubMed:35977029). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (PubMed:31439799, PubMed:32302570,…
May form homomultimers (PubMed:14764709). Interacts with G3BP1; interaction is direct and promotes stress granule formation (PubMed:17210633, PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572, PubMed:35977029, PubMed:36183834, PubMed:36279435). Interacts with G3BP2; interaction is direct and promotes stress granule formation (PubMed:27022092, PubMed:35977029). Interacts with…
Cytoplasm, Cytoplasmic ribonucleoprotein granule, Cytoplasm, cytosol, Cell projection, dendrite, Cell projection, lamellipodium
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9HFU | X-ray | 1.7 Å | C/D=426-442 |
| 6TA7 | X-ray | 1.93 Å | G/H=356-386 |
| 4WBE | X-ray | 2.05 Å | A/B/C=132-251 |
| 7XHG | X-ray | 2.46 Å | E/F/G=369-378 |
| 4WBP | X-ray | 2.5 Å | A/B=132-251 |
| 8TH7 | X-ray | 2.88 Å | C/D=360-381 |
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