Metabotropic glutamate receptor 4 (GRM4) is a 912-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14833.
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The mean pLDDT of this model is 83.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 53% |
| 70 to 90 | Confident: backbone generally right | 32% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity
Interacts with PICK1
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8JD4 | EM | 2.9 Å | 4=33-912 |
| 8JD6 | EM | 3.4 Å | R/S=33-912 |
| 8JD5 | EM | 3.6 Å | 4=33-912 |
| 8WGB | EM | 3.7 Å | R=33-912 |
| 7E9H | EM | 4.0 Å | R/S=33-912 |
| 8WGD | EM | 4.45 Å | B=33-912 |
| 8WG9 | EM | 4.46 Å | B=33-912 |
| 8WGC | EM | 5.95 Å | A=33-912 |
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