Early endosome antigen 1 (EEA1) is a 1411-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15075.
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The mean pLDDT of this model is 73.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 6% |
| 70 to 90 | Confident: backbone generally right | 65% |
| 50 to 70 | Low: treat with caution | 23% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking
Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. Interacts with SAMD9 and SAMD9L (PubMed:24029230). May interact with PLEKHF2
Early endosome membrane, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3MJH | X-ray | 2.03 Å | B/D=36-69 |
| 1JOC | X-ray | 2.2 Å | A/B=1287-1324, A/B=1326-1411 |
| 1HYI | NMR | A=1347-1411 | |
| 1HYJ | NMR | A=1347-1411 |
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