Splicing factor 3B subunit 3 (SF3B3) is a 1217-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15393.
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The mean pLDDT of this model is 92.3 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 79% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10490618, PubMed:10882114, PubMed:12234937, PubMed:27720643, PubMed:28781166, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:12234937, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex…
Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:11991638, PubMed:12234937, PubMed:15146077, PubMed:32494006, PubMed:34822310, PubMed:36797247). Part of the SF3B subcomplex of the 17S U2 SnRNP complex (PubMed:12234937, PubMed:12738865, PubMed:27720643, PubMed:28541300). SF3B associates with the…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Q4O | EM | 2.2 Å | C=1-1217 |
| 7Q4P | EM | 2.2 Å | C=1-1217 |
| 7Q3L | EM | 2.3 Å | C=1-1217 |
| 7B9C | X-ray | 2.4 Å | A=916-1216 |
| 9RDK | EM | 2.41 Å | A=1-1217 |
| 7EVO | EM | 2.5 Å | 3=1-1217 |
| 7EVN | EM | 2.6 Å | A=1-1217 |
| 8H6L | EM | 2.6 Å | 2I=1-1217 |
| 8H6K | EM | 2.7 Å | 2I=1-1217 |
| 8HK1 | EM | 2.7 Å | 3=1-1217 |
| 7DVQ | EM | 2.89 Å | 3=1-1217 |
| 7B0I | X-ray | 3.0 Å | A=1-442, A=768-1217 |
| 7B91 | X-ray | 3.0 Å | A=1-442, A=768-1216 |
| 7B92 | X-ray | 3.0 Å | A=1-442, A=768-1216 |
| 7OMF | X-ray | 3.0 Å | A=1-442, A=768-1217 |
| 7VPX | EM | 3.0 Å | 3=1-1217 |
| 8I0R | EM | 3.0 Å | 3=1-1217 |
| 8I0T | EM | 3.0 Å | 3=1-1217 |
| 8I0V | EM | 3.0 Å | 3=1-1217 |
| 6EN4 | X-ray | 3.08 Å | A=1-1217 |
Showing 20 of 64 experimental structures (best resolution first).
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