Nuclear receptor subfamily 0 group B member 2 (NR0B2) is a 257-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15466.
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The mean pLDDT of this model is 81.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 64% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (PubMed:22504882). Specifically inhibits transactivation of the nuclear receptor with which it interacts (PubMed:22504882). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (PubMed:14752053). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A…
Interacts (via N-terminus) with NEUROD1 (via N-terminus and C-terminus) (PubMed:14752053). Interacts with ID2 (PubMed:14752053). Interacts with RORG, NFIL3, NR1D1 and BHLHE41 (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein (PubMed:14752053). Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1 (PubMed:22504882). Interacts…
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6W9M | X-ray | 1.59 Å | B=17-27 |
| 4ONI | X-ray | 1.8 Å | C/D=12-30 |
| 1YUC | X-ray | 1.9 Å | C/D=15-28 |
| 4DOR | X-ray | 1.9 Å | C/D=15-28 |
| 5UFS | X-ray | 2.12 Å | C/D=18-27 |
| 7YXC | X-ray | 2.25 Å | R=17-27 |
| 7YXD | X-ray | 2.3 Å | C/F/J/N=17-28 |
| 2Q3Y | X-ray | 2.4 Å | B=18-27 |
| 7YXN | X-ray | 2.46 Å | R/S=17-27 |
| 7YXR | X-ray | 2.5 Å | R/S=17-28 |
| 2Z4J | X-ray | 2.6 Å | B=115-124 |
| 9HDF | X-ray | 2.78 Å | a/b/c/d/e/f/g/h/i/j/k/l/m/n/o/p=15-29 |
| 7YXO | X-ray | 2.99 Å | B/D/F=17-27 |
| 7YXP | X-ray | 3.36 Å | B=16-28 |
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