Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6) is a 494-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15825.
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The mean pLDDT of this model is 79.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). CHRNA6 forms pentameric channels with CHRNB2, CHRNB3 and CHRNA4 that exhibit high sensitivity to ACh and nicotine and are…
Neuronal AChR is composed of two different types of subunits: alpha and non-alpha (beta). CHRNA6/alpha-6 subunit can be combined to CHRNB2/beta-2, CHRNA4/alpha-4 and CHRNB3/beta-3 to give rise to functional receptors (PubMed:16835356). Heteropentamers containing CHRNB3 have an stoichiometry of (CHRNA6:CHRNB2)2:CHRNB3 (PubMed:16835356). Interacts with LYPD6 (PubMed:27344019)
Synaptic cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8ZRN | EM | 3.25 Å | A/C=1-374, A/C=416-494 |
| 8ZRP | EM | 3.32 Å | A/C=1-374, A/C=416-494 |
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