Hsp90 co-chaperone Cdc37 (CDC37) is a 378-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16543.
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The mean pLDDT of this model is 81.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 37% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206)
Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones STIP1/HOP, CDC37, PPP5C, PTGES3/p23, TSC1 and client protein TSC2 (PubMed:29127155). Probably forms a complex composed of chaperones HSP90 and HSP70, co-chaperones CDC37, PPP5C, TSC1 and client protein TSC2, CDK4, AKT, RAF1 and NR3C1; this complex does not contain co-chaperones STIP1/HOP and PTGES3/p23…
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2W0G | X-ray | 1.88 Å | A=148-276 |
| 5HPE | X-ray | 2.27 Å | A=5-20 |
| 1US7 | X-ray | 2.3 Å | B=127-378 |
| 9KQN | EM | 2.84 Å | E=1-378 |
| 7Z38 | EM | 3.16 Å | D=1-378 |
| 8GAE | EM | 3.3 Å | C=1-378 |
| 7ZR0 | EM | 3.4 Å | C=1-378 |
| 7Z37 | EM | 3.67 Å | DP1=1-378 |
| 8U1L | EM | 3.7 Å | D=1-378 |
| 8GFT | EM | 3.8 Å | C=1-378 |
| 5FWK | EM | 3.9 Å | E=1-378 |
| 7ZR5 | EM | 3.9 Å | C=1-378 |
| 7ZR6 | EM | 4.2 Å | C=1-378 |
| 5FWP | EM | 7.2 Å | E=1-378 |
| 5FWM | EM | 8.0 Å | E=1-378 |
| 5FWL | EM | 9.0 Å | E=1-378 |
| 2K5B | NMR | B=148-276 | |
| 2N5X | NMR | A=288-378 | |
| 2NCA | NMR | A=1-126 |
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