Bcl-2 homologous antagonist/killer (BAK1) is a 211-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16611.
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The mean pLDDT of this model is 81.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 34% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases
Homodimer. Formation of the homodimer is zinc-dependent (PubMed:17157251). Forms heterodimers with BCL2 and BCL2L1 isoform Bcl-X(L) (PubMed:9020082). Forms heterooligomers with BAX (PubMed:29531808). Interacts with BCL2A1 (By similarity). Interacts with RTL10/BOP (PubMed:23055042). Interacts with VDAC1 (PubMed:25296756). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771)
Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5VX1 | X-ray | 1.22 Å | A/B=23-186 |
| 8CZF | X-ray | 1.3 Å | A=23-186 |
| 8CZH | X-ray | 1.3 Å | A=23-186 |
| 2IMS | X-ray | 1.48 Å | A=16-186 |
| 2IMT | X-ray | 1.49 Å | A=16-186 |
| 5FMI | X-ray | 1.49 Å | A=23-184 |
| 9CPE | X-ray | 1.49 Å | A=20-186 |
| 7M5A | X-ray | 1.5 Å | A=21-186 |
| 5VWY | X-ray | 1.55 Å | A=23-186 |
| 5VX0 | X-ray | 1.6 Å | A/C=23-186 |
| 5VWZ | X-ray | 1.62 Å | A/C=23-186 |
| 6UXQ | X-ray | 1.7 Å | A/B/C/D=68-148 |
| 8IGC | X-ray | 1.7 Å | A=23-183 |
| 9CPF | X-ray | 1.7 Å | E/F/G/H=68-89 |
| 5FMK | X-ray | 1.73 Å | B=63-96 |
| 2JCN | X-ray | 1.8 Å | A=21-190 |
| 6UXO | X-ray | 1.8 Å | A/B/C/D/E/F/G/H/I/J/K/L=68-148 |
| 6UXR | X-ray | 1.8 Å | A/B=68-148 |
| 7M5B | X-ray | 1.85 Å | A/C=21-186 |
| 9CPN | X-ray | 1.89 Å | E/F/G/H=68-89 |
Showing 20 of 55 experimental structures (best resolution first).
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