2IMT: Apoptosis regulator BAK

Name: PDB 2IMT: The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site
Published: 2007-01-23
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: apoptosis

The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site. Determined by X-ray diffraction at 1.49 Å resolution. Released 23 Jan 2007.

Method: X-ray diffraction
Resolution: 1.49 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,422
Mol. weight: 19.24 kDa
Ligands: ZN
Released: 23 Jan 2007

Explore 2IMT in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

2IMT contains 11 α-helices and 0 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 11 helices, 0 β-strands

Element	Residues	Length
α-helix	24-50	27
α-helix	51-53	3
α-helix	55-56	2
α-helix	58-60	3
α-helix	70-85	16
α-helix	87-97	11
α-helix	104-119	16
α-helix	125-144	20
α-helix	151-164	14
α-helix	167-173	7
α-helix	177-182	6

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Apoptosis regulator BAK	A	protein	171	Homo sapiens	Q16611 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>2IMT_1 Apoptosis regulator BAK (chains A)
EPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVG
RQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFG
YRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNG

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	1

Primary citation

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site. Moldoveanu, T., Liu, Q., Tocilj, A. et al. Mol Cell (2006) 24:677-688. DOI 10.1016/j.molcel.2006.10.014 · PubMed

Other PDB entries of the same protein (UniProt Q16611 (AlphaFold model), which also has an AlphaFold model), best resolution first:

5VX1 1.22 Å, Bak L100A
8CZF 1.3 Å, Human BAK in complex with the dF2 peptide
8CZH 1.3 Å, Human BAK in complex with the dM2 peptide
2IMS 1.48 Å, The X-ray Structure of a Bak Homodimer Reveals an Inhibitory Zinc Binding Site
9CPE 1.49 Å, Structural basis of BAK sequestration by MCL-1 and consequences for apoptosis initiation
5FMI 1.49 Å, Human Bak Q77L
7M5A 1.5 Å, Crystal Structure of human BAK in complex with W3W5_BID
5VWY 1.55 Å, Bak core latch dimer in complex with Bim-h3Pc-RT
5VX0 1.6 Å, Bak in complex with Bim-h3Glg
5VWZ 1.62 Å, Bak in complex with Bim-h3Pc
6UXQ 1.7 Å, Crystal structure of BAK core domain BH3-groove-dimer in complex with POPC and C8E4
8IGC 1.7 Å, Crystal structure of Bak bound to Bnip5 BH3

Browse structure collections

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