Kazal-type trypsin inhibitor (AAEL006007) is a 91-residue protein from Aedes aegypti. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q177W0.
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The mean pLDDT of this model is 86.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 67% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Anticoagulant protein that decreases host thrombin (F2) activity via an uncompetitive inhibition mechanism (PubMed:20363282, PubMed:21167902). Inhibits amidolytic activity of host plasmin (PLG) (PubMed:20363282, PubMed:31726374, PubMed:34800067). Inhibits amidolytic activity of host trypsin (PubMed:20363282). Inhibits trypsin-like endogenous activity from gut of female mosquitoes 24 hours after feeding and weakly affects enzyme activity from gut 3 hours after feeding, suggesting a possible role as an inhibitor of endogenous proteases (PubMed:20363282)
Interacts with human PLG (plasmin)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
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