Actin-2 (ACT2) is a 376-residue protein from Plasmodium berghei (strain Anka). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q4YU79.
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The mean pLDDT of this model is 94.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 89% |
| 70 to 90 | Confident: backbone generally right | 8% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm (PubMed:24743229, PubMed:31199804). Polymerizes into longer and more stable actin filaments compared to ACT1/actin-1 (PubMed:24743229). Has ATPase activity (PubMed:24743229, PubMed:31199804). ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi (Probable). ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin (Probable). Plays an essential role in male gametocyte development in the mosquito midgut, functioning in several…
Monomer (G-actin) (PubMed:24743229, PubMed:31199804). Oligomer (F-actin) (PubMed:24743229, PubMed:31199804). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:24743229). Unlike for mammalian monomeric actin, monomeric actin is able to induce oligomerization with ATP or ADP (PubMed:24743229). Mg(2+), which is used to…
Cytoplasm, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
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