Centrosomal protein of 55 kDa (CEP55) is a 464-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q53EZ4.
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The mean pLDDT of this model is 82.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 14% |
What pLDDT means and how to read it
Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893). Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893). Not required for microtubule nucleation (PubMed:16198290). Plays a role in the development of the brain and kidney (PubMed:28264986)
Homodimer (PubMed:16406728). Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1; the interaction is indirect via the MTMR3:MTMR4 heterooligomer, occurs during early mitosis, regulates the phosphorylation of CEP55 by PLK1 and its recruitment to the midbody where it can mediate cell abscission (PubMed:16198290, PubMed:25659891). Interacts with AKAP9/CG-NAP; the interaction occurs in…
Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cleavage furrow, Midbody, Midbody ring, Midbody
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3E1R | X-ray | 2.0 Å | A/B=160-217 |
| 3WUT | X-ray | 2.3 Å | A/B/D/E/G/H/J/K=160-217 |
| 3WUV | X-ray | 2.79 Å | A/B/D/E/G/H/J/K/M/N/P/Q=160-217 |
| 3WUU | X-ray | 2.9 Å | A/B/D/E/G/H/J/K=160-217 |
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