Borealin (CDCA8) is a 280-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q53HL2.
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The mean pLDDT of this model is 67.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment
May form homooligomers and homodimers. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB or AURKC; in the complex forms a triple-helix bundle-based subcomplex with INCENP and BIRC5 (PubMed:17956729). Interacts with SENP3, UBE2I and RANBP2. Interacts (phosphorylated) with SGO1 and SGO2; the association is dependent on CDK1
Nucleus, nucleolus, Cytoplasm, Cytoplasm, cytoskeleton, spindle, Chromosome, centromere
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2QFA | X-ray | 1.4 Å | B=15-76 |
| 6YIF | X-ray | 1.81 Å | B=10-76 |
| 9D41 | X-ray | 1.84 Å | A=20-88 |
| 8RUQ | EM | 2.29 Å | L=1-76 |
| 2RAW | X-ray | 2.4 Å | B=20-78 |
| 8RUP | EM | 2.42 Å | L=1-76 |
| 6YIH | X-ray | 2.55 Å | B=10-76 |
| 7U5V | X-ray | 2.59 Å | C=137-145 |
| 9SI3 | EM | 2.83 Å | L/O=1-280 |
| 9SJ5 | EM | 2.85 Å | L/O=1-280 |
| 9SI9 | EM | 2.86 Å | L/O=1-280 |
| 2RAX | X-ray | 3.3 Å | B/F/Y=20-78 |
| 6YIE | X-ray | 3.49 Å | B/E=10-109 |
| 9SLJ | EM | 3.8 Å | L/O=1-280 |
| 2KDD | NMR | A/B=207-280 |
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