Secreted effector protein SifA (sifA) is a 336-residue protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q56061.
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The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required for endosomal tubulation and formation of Salmonella-induced filaments (Sifs), which are filamentous structures containing lysosomal membrane glycoproteins within epithelial cells. Sif formation is concomitant with intracellular bacterial replication
Interacts with host PLEKHM2. Interacts with SseJ; the interaction is indirect
Secreted, Host cytoplasm, Host cell membrane
Compare the prediction with experimentally determined structures of the same protein:
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