Rho GTPase-activating protein 21 (ARHGAP21) is a 1958-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5T5U3.
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The mean pLDDT of this model is 44.4 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 11% |
| 70 to 90 | Confident: backbone generally right | 9% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 76% |
What pLDDT means and how to read it
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions
Interacts with GTP-bound ARF1 and ARF6. Interacts with CTNNA1
Golgi apparatus membrane, Cell junction, Cytoplasmic vesicle membrane, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2J59 | X-ray | 2.1 Å | M/N/O/P/Q/R=930-1097 |
| 2DHJ | NMR | A=931-1042 | |
| 2YUY | NMR | A=47-159 |
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