Complement inhibitor is a 168-residue protein from Ornithodoros moubata. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5YD59.
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The mean pLDDT of this model is 90.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 1% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
Bifunctional protein derived from blood-feeding ticks that specifically prevents complement-mediated C5 activation and acts as a scavenger for inflammatory modulators such as leukotriene B4 (LTB4). C5 and LTB4 binding activities are independent (PubMed:23625922). Inhibits classical and alternative pathways of complement activation by preventing the cleavage of complement C5 by both classical and alternative C5 convertases (Probable) (PubMed:15699138). Inhibits complement in all species tested (rabbit, rat, guinea pig, mouse, pig, and human) (PubMed:27018802). Also binds fatty acids such as palmitoleic acid and ricinoleic acid, as well as inflammatory modulators LTB4 (and presumably…
Interacts with complement C5
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3ZUI | X-ray | 1.71 Å | A=19-168 |
| 3ZUO | X-ray | 1.86 Å | A/B/C/D=19-168 |
| 2CM4 | X-ray | 1.9 Å | A=19-168 |
| 2CM9 | X-ray | 2.3 Å | A=19-168 |
| 5HCC | X-ray | 2.59 Å | C=19-168 |
| 5HCD | X-ray | 2.98 Å | C=19-168 |
| 5HCE | X-ray | 3.12 Å | C=19-168 |
| 6RQJ | EM | 3.5 Å | C=19-168 |
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