Cysteine protease RavZ (ravZ) is a 502-residue protein from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5ZUV9.
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The mean pLDDT of this model is 82.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 66% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Cysteine protease effector that inhibits host cell autophagy by targeting lipid-conjugated ATG8 family proteins on pre-autophagosomal structures (PubMed:23112293, PubMed:26343456, PubMed:28395732, PubMed:29458288, PubMed:31719622, PubMed:31722778, PubMed:32686895, PubMed:33298241). Specifically hydrolyzes the amide bond between the C-terminal glycine residue and an adjacent aromatic residue in ATG8 proteins conjugated to phosphatidylethanolamine (PE), producing an ATG8 protein that cannot be reconjugated by host ATG7 and ATG3 (PubMed:23112293, PubMed:26343456, PubMed:28395732, PubMed:29458288, PubMed:32686895). Mechanistically, Ravz interacts with ATG8 proteins conjugated to PE via its LIR…
Secreted, Host cytoplasmic vesicle membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5MS5 | X-ray | 1.53 Å | A/B=24-36 |
| 5XAD | X-ray | 1.88 Å | C/D=12-34 |
| 5MS2 | X-ray | 2.47 Å | A=1-431 |
| 5HZY | X-ray | 2.55 Å | A=49-502 |
| 5IO3 | X-ray | 2.74 Å | A=1-502 |
| 5MS7 | X-ray | 2.8 Å | A=20-502 |
| 5IZV | X-ray | 2.81 Å | A/B=1-502 |
| 5MS8 | X-ray | 2.85 Å | A=1-487 |
| 5CQC | X-ray | 2.98 Å | A=10-458 |
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