Transcriptional enhancer factor TEF-3 (Tead4) is a 427-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q62296.
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The mean pLDDT of this model is 76.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 22% |
What pLDDT means and how to read it
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC…
Interacts with WWTR1/TAZ (By similarity). Interacts with YAP1
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6SBA | X-ray | 1.3 Å | A=209-427 |
| 5XJD | X-ray | 2.22 Å | A/B=210-427 |
| 6L9F | X-ray | 2.56 Å | A/B=209-427 |
| 5Z2Q | X-ray | 2.74 Å | A/B=210-426 |
| 4LN0 | X-ray | 2.9 Å | A/B=209-427 |
| 5GN0 | X-ray | 2.9 Å | A/B/C/D=210-427 |
| 3JUA | X-ray | 3.0 Å | A/C/E/G=210-427 |
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