Activity-regulated cytoskeleton-associated protein (Arc) is a 396-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q63053.
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The mean pLDDT of this model is 64.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 6% |
| 70 to 90 | Confident: backbone generally right | 49% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 36% |
What pLDDT means and how to read it
Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (PubMed:29328916). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (PubMed:29328916). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (PubMed:29328916). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory…
Homooligomer; homooligomerizes into virion-like capsids (PubMed:29328916, PubMed:30028513, PubMed:31080121). Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2 (PubMed:17088211). Interacts with CAMK2B (in the kinase inactive state); leading to target ARC to inactive synapses (PubMed:22579289). Interacts with PSEN1 (By similarity). Interacts with GRIN2A and GRIN2B; inhibiting…
Extracellular vesicle membrane, Postsynaptic cell membrane, Synapse, Postsynaptic density, Early endosome membrane, Cell projection, dendrite, Cytoplasm, cytoskeleton, Cytoplasm, cell cortex, Cell projection, dendritic spine, Cytoplasmic vesicle, secretory vesicle, acrosome, Cytoplasmic vesicle,…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4X3I | X-ray | 1.8 Å | A=207-277 |
| 4X3X | X-ray | 2.0 Å | A=277-362 |
| 4X3H | X-ray | 2.4 Å | A=207-277 |
| 7R24 | X-ray | 2.7 Å | A=1-396 |
| 6GSE | NMR | A=206-364 |
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