Male-specific lethal 1 homolog (MSL1) is a 614-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q68DK7.
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The mean pLDDT of this model is 57.6 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 14% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 56% |
What pLDDT means and how to read it
Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage…
Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:30224647, PubMed:33837287). Forms a MSL heterotetrameric core with MSL2 (PubMed:16227571). Interacts (via PEHE domain) with KAT8 (via HAT domain) and MSL3 (via MRG domain); both…
Nucleus, Nucleus, nucleoplasm, Nucleus speckle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4DNC | X-ray | 2.05 Å | D/E=473-520 |
| 4B7Y | X-ray | 3.25 Å | A/B=212-252 |
| 4B86 | X-ray | 3.5 Å | A/B/E/F/I/J=212-267 |
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