BTB/POZ domain-containing protein KCTD16 (KCTD16) is a 428-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q68DU8.
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The mean pLDDT of this model is 69.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 36% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity)
Homopentamer; forms an open pentamer (PubMed:28963344). In contrast to other BTB domain-containing proteins, does not interact with CUL3 (PubMed:28963344). Interacts as a tetramer with GABRB1 and GABRB2
Presynaptic cell membrane, Postsynaptic cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6QB7 | X-ray | 2.23 Å | A/B/C/D/E=126-286 |
| 6OCR | X-ray | 2.28 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=22-134 |
| 6I0Q | X-ray | 2.3 Å | A=22-124 |
| 6OCP | X-ray | 2.35 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=22-134 |
| 5A15 | X-ray | 2.76 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=16-133 |
| 6OCT | X-ray | 2.8 Å | A/B/C/D/E/F/G/H/I/J=22-134 |
| 6M8R | X-ray | 3.2 Å | A/B/C/D/E/F/G/H/I/J=23-124 |
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