NACHT, LRR and PYD domains-containing protein 14 (Nlrp14) is a 993-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6B966.
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The mean pLDDT of this model is 86.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Component of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:41845018, PubMed:41917274, PubMed:41986725). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:41845018, PubMed:41917274, PubMed:41986725). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a…
Component of cytoplasmic lattices, at least composed of PADI6, NLRP4F, NLRP5, NLRP14, TLE6, KHDC3, OOEP and ZBED3 (PubMed:41845018, PubMed:41917274, PubMed:41986725). Cytoplasmic lattices form a filamentous architecture; the external framework is built from PADI6 decamers and the subcortical maternal complexes (SCMC) (PubMed:41845018, PubMed:41917274, PubMed:41986725). Two linkers formed by…
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9WSR | EM | 2.79 Å | A=234-993 |
| 9WSQ | EM | 3.35 Å | A=234-993 |
| 9XRL | EM | 3.74 Å | AK/AQ/w=29-991 |
| 9SFP | EM | 4.2 Å | J=1-993 |
| 9W2M | EM | 4.2 Å | N/n=28-993 |
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