9W2M: Cytoplasmic lattice(CPL) from mouse oocyte

Cryo-EM structure of the Cytoplasmic lattice(CPL) from mouse oocyte. Determined by electron microscopy at 4.2 Å resolution. Released 25 Feb 2026.

Method: Electron microscopy
Resolution: 4.2 Å
Organism: Mus musculus
Chains: 56
Atoms: 234,055
Mol. weight: 3656.58 kDa
Ligands: ADP, GDP
Released: 25 Feb 2026

Explore 9W2M in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9W2M contains 1,206 α-helices and 1,642 β-strands across 54 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain 1: 35 helices, 56 β-strands

Element	Residues	Length	Sheet
β-strand	6-7	2	1
β-strand	15-20	6	2
β-strand	25-27	3	1
α-helix	35-37	3
β-strand	40-44	5	2
β-strand	48-49	2	3
β-strand	50-51	2	4
β-strand	56-57	2	4
β-strand	67	1	2
α-helix	73-74	2
β-strand	75-77	3	1
β-strand	78-79	2	3
β-strand	89-95	7	2
α-helix	104	1
β-strand	105-114	10	2
β-strand	115-119	5	5
α-helix	136-138	3
β-strand	149-151	3	6
β-strand	153	1	5
α-helix	157-159	3
α-helix	172-177	6
β-strand	179-186	8	5
α-helix	189-193	5
β-strand	195-201	7	6
α-helix	203-208	6
β-strand	209-213	5	5
β-strand	222-225	4	5
β-strand	226	1	7
β-strand	229	1	7
β-strand	231-234	4	6
α-helix	235-237	3
β-strand	242-249	8	5
β-strand	254	1	8
β-strand	257	1	8
β-strand	260-269	10	6
α-helix	277-278	2
β-strand	279-290	12	6
α-helix	291	1
β-strand	294	1	9
α-helix	301	1
β-strand	302-308	7	10
α-helix	315-327	13
β-strand	330-334	5	10
α-helix	341	1
α-helix	344-347	4
β-strand	349-355	7	9
β-strand	360-366	7	9
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	9
α-helix	404-406	3
β-strand	408-409	2	11
α-helix	410-411	2
β-strand	413-415	3	12
β-strand	418-420	3	12
β-strand	425-426	2	11
β-strand	429	1	13
β-strand	439	1	13
α-helix	442-449	8
β-strand	456-457	2	11
β-strand	464	1	14
α-helix	469-471	3
β-strand	473-477	5	15
β-strand	488-494	7	15
α-helix	495-508	14
β-strand	514	1	16
α-helix	521-527	7
β-strand	533	1	16
α-helix	534-539	6
α-helix	541-565	25
α-helix	569-571	3
β-strand	572-576	5	15
β-strand	579-582	4	14
α-helix	589-591	3
β-strand	597-600	4	14
β-strand	610-611	2	17
β-strand	614-615	2	17
α-helix	617	1
β-strand	618	1	18
α-helix	619	1
β-strand	624-625	2	19
β-strand	628-629	2	19
α-helix	630-639	10
α-helix	640-642	3
β-strand	645-646	2	17
β-strand	649	1	18
α-helix	652-656	5
α-helix	657-658	2
β-strand	665-670	6	10
α-helix	671-673	3
α-helix	677-679	3

Chain 11: 35 helices, 52 β-strands

Element	Residues	Length	Sheet
β-strand	6-7	2	371
β-strand	15-20	6	372
β-strand	25-27	3	371
α-helix	35-37	3
β-strand	40-44	5	372
β-strand	49-52	4	371
β-strand	55-57	3	371
β-strand	67	1	372
α-helix	73-74	2
β-strand	75-78	4	371
α-helix	82-83	2
β-strand	89-95	7	372
α-helix	96-98	3
β-strand	107-114	8	372
β-strand	115-119	5	373
α-helix	136-138	3
β-strand	149-151	3	374
β-strand	153	1	373
α-helix	157-159	3
α-helix	172-177	6
β-strand	179-186	8	373
α-helix	189-193	5
β-strand	195-201	7	374
α-helix	203-208	6
β-strand	209-213	5	373
β-strand	222-225	4	373
β-strand	226	1	375
β-strand	229	1	375
β-strand	231-234	4	374
α-helix	235-237	3
β-strand	242-249	8	373
β-strand	254	1	376
β-strand	257	1	376
β-strand	260-269	10	374
α-helix	277-278	2
β-strand	279-290	12	374
α-helix	291	1
β-strand	294	1	377
α-helix	301	1
β-strand	302-308	7	378
α-helix	315-327	13
β-strand	330-334	5	378
α-helix	341	1
α-helix	344-347	4
β-strand	349-355	7	377
β-strand	360-366	7	377
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	377
α-helix	404-406	3
β-strand	408-409	2	379
α-helix	410-411	2
β-strand	413-415	3	380
β-strand	418-420	3	380
β-strand	425-426	2	379
β-strand	429	1	381
β-strand	439	1	381
α-helix	442-449	8
β-strand	456-457	2	379
β-strand	464	1	382
α-helix	469-471	3
β-strand	473-477	5	383
β-strand	488-494	7	383
α-helix	495-508	14
α-helix	513	1
β-strand	514	1	384
α-helix	521-527	7
β-strand	533	1	384
α-helix	534-539	6
α-helix	541-565	25
α-helix	569-571	3
β-strand	572-576	5	383
β-strand	579-582	4	382
α-helix	589-591	3
β-strand	597-600	4	382
β-strand	609-611	3	385
β-strand	614-618	5	385
β-strand	624-625	2	386
β-strand	628-629	2	386
α-helix	630-639	10
α-helix	640-642	3
β-strand	645-649	5	385
α-helix	652-656	5
α-helix	657-658	2
β-strand	665-670	6	378
α-helix	671-673	3
α-helix	677-679	3

Chain 12: 25 helices, 48 β-strands

Element	Residues	Length	Sheet
β-strand	6-8	3	179
β-strand	17-20	4	180
β-strand	25-28	4	179
β-strand	39-43	5	180
β-strand	48-52	5	179
β-strand	55-57	3	179
β-strand	65-67	3	180
β-strand	74-79	6	179
β-strand	89-96	8	180
β-strand	103-114	12	180
β-strand	115-119	5	181
β-strand	150-151	2	182
β-strand	153	1	181
α-helix	172-177	6
β-strand	179-186	8	181
α-helix	189-192	4
β-strand	195-200	6	183
α-helix	203-206	4
β-strand	209-214	6	181
β-strand	221-225	5	181
β-strand	226	1	184
β-strand	229	1	184
β-strand	231-233	3	183
α-helix	234-236	3
β-strand	243-249	7	181
β-strand	261-269	9	183
α-helix	270-271	2
β-strand	279-288	10	183
β-strand	289-290	2	182
β-strand	294-295	2	185
α-helix	296-297	2
α-helix	301	1
β-strand	302-307	6	186
α-helix	315-326	12
β-strand	330-333	4	186
α-helix	344-347	4
β-strand	349-355	7	185
β-strand	360-366	7	185
α-helix	378-381	4
α-helix	383	1
β-strand	386-390	5	185
α-helix	404-406	3
β-strand	407-409	3	187
β-strand	425-429	5	187
α-helix	442-449	8
β-strand	457-460	4	187
β-strand	464	1	188
β-strand	473-477	5	189
β-strand	488-493	6	189
α-helix	495-508	14
β-strand	514	1	190
α-helix	521-527	7
β-strand	533	1	190
α-helix	534-539	6
α-helix	542-565	24
α-helix	569-571	3
β-strand	572-575	4	189
β-strand	580-582	3	188
α-helix	589-591	3
β-strand	597-599	3	188
β-strand	611	1	191
β-strand	614	1	191
α-helix	617	1
β-strand	618	1	192
α-helix	619	1
β-strand	624	1	193
β-strand	629	1	193
α-helix	630-639	10
α-helix	640-642	3
β-strand	649	1	192
α-helix	652-655	4
α-helix	657-658	2
β-strand	666-670	5	186

Chain 13: 28 helices, 52 β-strands

Element	Residues	Length	Sheet
β-strand	6-8	3	67
β-strand	17-20	4	68
β-strand	25-28	4	67
β-strand	39-43	5	68
β-strand	45	1	69
β-strand	48	1	69
β-strand	50-52	3	67
β-strand	55-57	3	67
β-strand	64-67	4	68
β-strand	74-77	4	67
β-strand	89-96	8	68
β-strand	97	1	70
β-strand	100	1	70
β-strand	107-114	8	68
β-strand	115-119	5	71
β-strand	141	1	72
β-strand	147	1	72
β-strand	150-151	2	73
α-helix	152	1
β-strand	153	1	71
α-helix	154	1
α-helix	172-177	6
β-strand	179-186	8	71
α-helix	189-192	4
β-strand	195-200	6	73
α-helix	203-208	6
β-strand	209-213	5	71
β-strand	222-225	4	71
β-strand	231-233	3	73
α-helix	234-237	4
β-strand	242-249	8	71
β-strand	260-269	10	73
α-helix	270-271	2
β-strand	273	1	74
β-strand	276	1	74
β-strand	280-290	11	73
β-strand	294	1	75
α-helix	301	1
β-strand	302-308	7	76
α-helix	315-327	13
β-strand	330-333	4	76
α-helix	341	1
α-helix	344-347	4
β-strand	351-356	6	75
β-strand	359-366	8	75
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	75
α-helix	404-406	3
β-strand	407-410	4	77
α-helix	411-412	2
β-strand	414-415	2	78
β-strand	418-419	2	78
β-strand	424-427	4	77
α-helix	439-441	3
α-helix	442-449	8
β-strand	457-458	2	77
β-strand	464	1	79
α-helix	469-471	3
β-strand	473-477	5	80
β-strand	488-494	7	80
α-helix	495-508	14
α-helix	513	1
β-strand	514	1	81
α-helix	521-527	7
β-strand	533	1	81
α-helix	534-539	6
α-helix	541-565	25
β-strand	572-576	5	80
β-strand	579-583	5	79
β-strand	596-600	5	79
α-helix	608	1
β-strand	609-611	3	82
β-strand	614-618	5	82
α-helix	633-639	7
α-helix	640-642	3
β-strand	645-649	5	82
α-helix	652-655	4
α-helix	657-658	2
β-strand	665-670	6	76

Chain 14: 28 helices, 52 β-strands

Element	Residues	Length	Sheet
β-strand	6	1	34
β-strand	15-20	6	35
β-strand	21	1	36
β-strand	24-27	4	34
β-strand	39-44	6	35
β-strand	50-52	3	34
β-strand	56-57	2	34
β-strand	67-68	2	35
β-strand	75-78	4	34
β-strand	79	1	36
β-strand	89-96	8	35
β-strand	105-114	10	35
β-strand	115-119	5	37
α-helix	134-138	5
β-strand	149-151	3	38
β-strand	153	1	37
α-helix	157-159	3
α-helix	172-177	6
β-strand	179-186	8	37
α-helix	189-192	4
β-strand	195-200	6	38
α-helix	203-206	4
β-strand	209-213	5	37
β-strand	222-225	4	37
β-strand	226	1	39
β-strand	229	1	39
β-strand	231-233	3	38
α-helix	234-236	3
β-strand	242-249	8	37
α-helix	252-253	2
β-strand	254	1	40
β-strand	257	1	40
β-strand	260-269	10	38
α-helix	270-271	2
β-strand	279-290	12	38
β-strand	294-295	2	41
α-helix	301	1
β-strand	302-309	8	42
α-helix	315-327	13
β-strand	330-335	6	42
α-helix	344-347	4
β-strand	349-355	7	41
β-strand	360-366	7	41
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	41
α-helix	404-406	3
β-strand	407-409	3	43
β-strand	413-415	3	44
β-strand	418-420	3	44
β-strand	425-427	3	43
β-strand	429	1	45
β-strand	439	1	45
α-helix	442-449	8
β-strand	456-458	3	43
β-strand	464	1	46
α-helix	469-471	3
β-strand	473-477	5	47
β-strand	488-494	7	47
α-helix	495-508	14
α-helix	513-514	2
α-helix	521-527	7
α-helix	534-539	6
α-helix	542-565	24
α-helix	569-571	3
β-strand	572-576	5	47
β-strand	579-583	5	46
β-strand	596-600	5	46
β-strand	609-611	3	48
β-strand	614-618	5	48
β-strand	624-625	2	49
β-strand	628-629	2	49
α-helix	630-639	10
α-helix	640-642	3
β-strand	645-649	5	48
α-helix	652-655	4
α-helix	657-658	2
β-strand	665-670	6	42
α-helix	671-673	3
α-helix	677-679	3

Chain 15: 27 helices, 47 β-strands

Element	Residues	Length	Sheet
β-strand	15-19	5	434
β-strand	21	1	435
β-strand	24-27	4	435
β-strand	39-42	4	434
β-strand	48-52	5	435
β-strand	55-57	3	435
β-strand	65-68	4	434
β-strand	75-79	5	435
β-strand	90-96	7	434
β-strand	105-113	9	434
β-strand	115-119	5	436
α-helix	134-138	5
β-strand	149-151	3	437
α-helix	157-159	3
α-helix	172-177	6
β-strand	179-186	8	436
α-helix	189-194	6
β-strand	197-200	4	437
α-helix	203-208	6
β-strand	209-213	5	436
β-strand	222-225	4	436
β-strand	231-234	4	437
α-helix	235	1
β-strand	243-249	7	436
β-strand	260-269	10	437
β-strand	279-290	12	437
α-helix	291-292	2
β-strand	293-295	3	438
α-helix	296-297	2
α-helix	301	1
β-strand	302-308	7	439
α-helix	315-327	13
β-strand	330-334	5	439
α-helix	344-348	5
β-strand	349-355	7	438
β-strand	360-366	7	438
α-helix	378-381	4
α-helix	383	1
β-strand	387-390	4	438
β-strand	407-410	4	440
α-helix	411-412	2
β-strand	413-415	3	441
β-strand	418-420	3	441
β-strand	424-427	4	440
α-helix	442-451	10
β-strand	456-458	3	440
β-strand	464	1	442
α-helix	469-471	3
β-strand	473-476	4	443
β-strand	489-493	5	443
α-helix	495-505	11
α-helix	506-510	5
β-strand	514	1	444
β-strand	515	1	445
α-helix	521-527	7
β-strand	533	1	444
α-helix	534-539	6
α-helix	541-565	25
α-helix	569-571	3
β-strand	572-575	4	443
β-strand	579-582	4	442
α-helix	589-591	3
β-strand	597-600	4	442
β-strand	609-611	3	446
β-strand	614-616	3	446
β-strand	623	1	445
β-strand	624-625	2	447
β-strand	628-629	2	447
α-helix	630-639	10
α-helix	640-642	3
β-strand	645-646	2	446
α-helix	652-655	4
β-strand	665-670	6	439
α-helix	671-673	3

Chain 16: 25 helices, 51 β-strands

Element	Residues	Length	Sheet
β-strand	7-8	2	464
β-strand	15-20	6	465
β-strand	25-28	4	464
α-helix	29-31	3
β-strand	39-41	3	465
β-strand	44	1	465
β-strand	49-51	3	464
β-strand	57-58	2	464
β-strand	67-68	2	465
β-strand	74-78	5	464
β-strand	90-96	7	465
β-strand	105-114	10	465
β-strand	115-117	3	466
β-strand	149-151	3	467
β-strand	153	1	468
α-helix	172-177	6
β-strand	179-181	3	468
β-strand	184-186	3	466
α-helix	189-192	4
β-strand	195-200	6	469
α-helix	203-208	6
β-strand	209-214	6	468
β-strand	221-225	5	468
β-strand	231-234	4	469
β-strand	245-249	5	468
β-strand	260-262	3	467
β-strand	264-269	6	469
α-helix	270-271	2
β-strand	280	1	469
β-strand	284	1	469
β-strand	287-290	4	467
β-strand	293-295	3	470
α-helix	301	1
β-strand	302-308	7	471
α-helix	315-327	13
β-strand	331-333	3	471
α-helix	334-337	4
α-helix	344-347	4
β-strand	349-354	6	470
β-strand	361-366	6	470
α-helix	377-381	5
α-helix	383	1
β-strand	387-390	4	470
α-helix	404-406	3
β-strand	408-409	2	472
α-helix	410-411	2
β-strand	413-415	3	473
β-strand	418-420	3	473
β-strand	425-427	3	472
α-helix	442-451	10
β-strand	457-458	2	472
β-strand	464	1	474
α-helix	469-471	3
β-strand	473-476	4	475
β-strand	489-493	5	475
α-helix	495-505	11
α-helix	506-510	5
β-strand	514	1	476
α-helix	521-526	6
β-strand	533	1	476
α-helix	534-539	6
α-helix	541-564	24
β-strand	572-575	4	475
β-strand	579-583	5	474
β-strand	596-600	5	474
β-strand	609-611	3	477
β-strand	614-618	5	477
α-helix	619	1
β-strand	624-625	2	478
β-strand	628-629	2	478
α-helix	630-639	10
β-strand	646-649	4	477
α-helix	652-656	5
α-helix	657-658	2
β-strand	665-670	6	471
α-helix	671-673	3

Chain 17: 27 helices, 51 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15-20	6	102
β-strand	25-28	4	103
β-strand	39-44	6	102
β-strand	48-52	5	103
β-strand	55-57	3	103
β-strand	65-68	4	102
β-strand	74-79	6	103
β-strand	89-96	8	102
β-strand	105-114	10	102
β-strand	115-119	5	104
α-helix	134-137	4
β-strand	141	1	105
β-strand	147	1	105
β-strand	150-151	2	106
β-strand	153	1	107
α-helix	157-159	3
α-helix	172-176	5
β-strand	179-186	8	104
α-helix	189-192	4
β-strand	195-201	7	108
α-helix	203-206	4
β-strand	210-213	4	104
β-strand	222-225	4	104
β-strand	226	1	109
β-strand	229	1	109
β-strand	231-233	3	108
α-helix	234-237	4
β-strand	242-248	7	104
β-strand	249	1	107
β-strand	254	1	110
β-strand	257	1	110
β-strand	261-269	9	108
β-strand	279-288	10	108
β-strand	289-290	2	106
β-strand	294	1	111
α-helix	301	1
β-strand	302-308	7	112
α-helix	315-327	13
β-strand	330-334	5	112
α-helix	335-337	3
α-helix	344-347	4
β-strand	349-356	8	111
β-strand	359-366	8	111
α-helix	378-381	4
α-helix	383	1
β-strand	387-390	4	111
α-helix	404-406	3
β-strand	407-409	3	113
β-strand	413-415	3	114
β-strand	418-420	3	114
β-strand	425-427	3	113
β-strand	429	1	115
β-strand	439	1	115
α-helix	442-449	8
β-strand	456-458	3	113
β-strand	464	1	116
α-helix	469-471	3
β-strand	473-477	5	117
β-strand	488-494	7	117
α-helix	495-508	14
α-helix	521-527	7
α-helix	534-539	6
α-helix	542-565	24
α-helix	569-571	3
β-strand	572-576	5	117
β-strand	579-583	5	116
β-strand	596-600	5	116
β-strand	610-611	2	118
β-strand	614-618	5	118
α-helix	619	1
α-helix	625-627	3
α-helix	630-639	10
α-helix	640-642	3
β-strand	645-649	5	118
α-helix	652-656	5
β-strand	665-670	6	112
α-helix	671-673	3

39 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Inactive protein-arginine deiminase type-6	1, 11, 12, 13, 14, 15, 16, 17, 18, 19, 2, 3, 4, 5, 6, 7, 8, 9, Z, z	protein	682	Mus musculus	Q8K3V4 (AlphaFold model)
Oocyte-expressed protein homolog	C, H, c, h	protein	125	Mus musculus	Q9CWE6 (AlphaFold model)
KH domain-containing protein 3	D, d	protein	128	Mus musculus	Q9CWU5 (AlphaFold model)
NLR family, pyrin domain containing 4F	E, I, e, i	protein	933	Mus musculus	L7N1W9 (AlphaFold model)
FBXW24	J, j	protein	466	Mus musculus
S-phase kinase-associated protein 1	K, k	protein	163	Mus musculus	Q9WTX5
Ubiquitin-conjugating enzyme E2 D3	O, o	protein	147	Mus musculus	P61079
E3 ubiquitin-protein ligase UHRF1	P, Q, p, q	protein	782	Mus musculus	Q8VDF2
Zinc finger BED domain-containing protein 3	R, r	protein	55	Mus musculus	Q9D0L1
NACHT, LRR and PYD domains-containing protein 14	N, n	protein	966	Mus musculus	Q6B966
Tubulin beta-2A chain	L, l	protein	445	Mus musculus	Q7TMM9
Tubulin beta-2B chain	M, m	protein	445	Mus musculus	Q9CWF2

2 more molecules are not listed.

Sequence of entity 1 (1, 11, 12, 13, 14, 15, 16, 17, 18, 19, 2, 3, 4, 5, 6, 7, 8, 9, Z, z), FASTA

>9W2M_1 Inactive protein-arginine deiminase type-6 (chains 1, 11, 12, 13, 14, 15, 16, 17, 18, 19, 2, 3, 4, 5, 6, 7, 8, 9, Z, z)
MSFQNSLSLSLVNPTHALCMVGMEITLDISKCAPDKCKSFTIRGSPRILIHISSSVIAGK
EDTVVWRSMNHPTVALVRMVAPSPTVDEDKVLVSYFCPDQEVPTATAVLFLTGIEISLEA
DIYRDGQLDMPSDKQAKKKWMWGMNGWGAILLVNCSPNAVGQPDEQSFQEGPREIQNLSQ
MNVTVEGPTSILQNYQLILHTSEEEAKKTRVYWSQRGSSAYELVVGPNKPVYLLPTFENR
RKEAFYVEATEFPSPSFSGLISLSLSLVEKAHDECIPEIPLYKDTVMFRVAPYIFMPSTQ
MPLEVYLCRELQLQGFVDSVTKLSEKSKVQVVKVYEDPNRQSKWLQDEMAFCYTQAPHKT
VSLILDTPRVSKLEDFPMKYTLTPGSGYLIRQTEDHRVASLDSIGNLMVSPPVKAQGKDY
PLGRVLIGGSFYPSSEGRDMNKGLREFVYAQQVQAPVELFSDWLMTGHMDQFMCFVPTND
KNNDQKDFRLLLASPSACFELFEQKQKEGYGNVTLFEDIGAEQLLSNGRESKTISQILAD
KSFREQNTYVEKCISLNRTLLKTELGLEDKDIILIPQLFCLEQLTNVPSNQQSTKLFARP
YFPDMLQIIVLGKNLGIPKPFGPKINGTCCLEEKVCGLLEPLGLKCTFIDDFDCYLANIG
DVCASAIINRVPFAFKWWKMTP

Sequence of entity 2 (C, H, c, h), FASTA

>9W2M_2 Oocyte-expressed protein homolog (chains C, H, c, h)
NVLPVSLRLRTRPWWFPIQEVSNPLVLYMEAWVAERVIGTDQAEISEIEWMCQALLTVDS
VNSGNLAEITIFGQPSAQTRMKNILLNMAAWHKENELQRAVKVKEVEEFLKIRASSILSK
LSKKG

Sequence of entity 3 (D, d), FASTA

>9W2M_3 KH domain-containing protein 3 (chains D, d)
MASLKRFQTLVPLDHKQGTLFEIIGEPKLPKWFHVECLEDPKRLYVEPRLLEIMFGKDGE
HIPHLESMLHTLIHVNVWGPERRAEIWIFGPPPFRRDVDRMLTDLAHYCRMKLMEIEALE
AGVERRRM

Sequence of entity 4 (E, I, e, i), FASTA

>9W2M_4 NLR family, pyrin domain containing 4F (chains E, I, e, i)
ISDFGLIWYLRELNKKEFMKFKDFLIQEILELKLKQVSSTKVKKASREDLANLLLKCGEN
QAWDMTFRILQKINRKDLTERATGAIVGNPNLYRDHLKKKLTHDCPKKFNVRIQDFIKET
FIQNDYDAFENLLISKGTERKPHMVFLKGMAGVGKTLMLKNLMLAWSKGLVFQNKFSYAF
YFCCQDVKQLKTASLAELISREWPSPSAPIEEILSQPEKLLFIIDSLEGMEWDLTKQESE
LCDDCMEKQPVSTLLSSLLRRKMLPESSLLLSTTPETFEKMEDRIQCTDVKTATAFDERS
MKIYFHRLFQDRKRAQEAFSLVRENKQLFTICQVPLLCWMVATCLKEEIEKGGDPVSLCR
RTTSLYTTHIFSLFIPQSAQYPSKKSQDQLQGLCSLAAEGMWTDTFVFGKEALRRNGIFD
SDIPTLLDIGMLGKIREFENSYIFLHPSVQEVCAAIFYMLKRHVEHPSQDVKNIETVLFM
FLKKVKTQWIFLGCFIFGLLQKSEQEKLGVFFGHRLSKNIHHKLYQCLETLSGNAELQEQ
IDGMRLFSCLFEMEDEAFLVKAMNCMQQINFVAKNYSDFIVAAYCLKHCSTLKKLSFSTE
NVLNEGDQSYMEELLICWNNMCSVFVRSKDIQELRIKDTNFNEPAIRVLYESLKYPSFTL
NKLVANNVSFGDNHVLFELIQNSSLQYLDLSCSFLSHNEVKLLCDILNQAECNIEKLMIA
HCKLSPDDCKIFGSILMSSKSLKVLNLASNNLNQGISSLCKALCHPHCTLEYLVLSNCSL
SEQCWDYLSEVLRQNKTLSHLDISSNDLKDEGLKILCRSLILPYCVLESLCLSCCGITER
GCQDLAEVLKNNQNLKYLHVSYNKLKDTGVMLLCDAIKHPNCHLKDLQLEACEITDASNE
ELCYAFMQCETLQTLNLMGNAFEVSRMVFFPRF

Sequence of entity 5 (J, j), FASTA

>9W2M_5 FBXW24 (chains J, j)
MEIHLSSFPMMEIFSYLDAYSLLQVAQVNKNWNALASNDFLWRKLCQERWLFCDMVTLQL
LGKETWKQFFVYRTWQEHVKSRAIPEDFTYKEIPLECGVRGYAGYISGCALTRNGQGKSV
VCMVSSKNKISTWDISESVITWVSPVQPASIKLLTTLPDMHIAVTVDIQSTIKLWDCHNR
EALATNNLESPCKSLKAVISKDGPIVLAGDILGNLYIFRIPDLHLISTVNVFPCGFDKID
CSPQKKWVLLSQNHPCIYPKVFYMSSLLRTSEFSDPVSTVLEFSLCKRAFWTPRREDRIT
LMSRRGRPIVTRFETFDMKLEENGNKTIVKGDLVASFSLQDYNENPKWMGVSDKSVIVCS
TGSSLLLFSMKGLHLQTFQYSPEMIVRLWVDPVHVIITCNDGSIDVYMWEERSLLLKMCY
RLQNGRHLPPFGFIKNLLCDDVSIVQLMIDRQGPCFLMAYTLNICS

Sequence of entity 6 (K, k), FASTA

>9W2M_6 S-phase kinase-associated protein 1 (chains K, k)
MPTIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQ
WCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTC
KTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK

Sequence of entity 7 (O, o), FASTA

>9W2M_7 Ubiquitin-conjugating enzyme E2 D3 (chains O, o)
MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDRDKYNRISREWTQKYAM

Sequence of entity 8 (P, Q, p, q), FASTA

>9W2M_8 E3 ubiquitin-protein ligase UHRF1 (chains P, Q, p, q)
MWIQVRTMDGKETHTVNSLSRLTKVQELRKKIEEVFHVEPQLQRLFYRGKQMEDGHTLFD
YDVRLNDTIQLLVRQSLALPLSTKERDSELSDSDSGYGVGHSESDKSSTHGEGAAEADDK
TVWEDTDLGLYKVNEYVDVRDNIFGAWFEAQVVQVQKRALSEDEPCSSSAVKTSEDDIMY
HVKYDDYPEHGVDIVKAKNVRARARTVIPWENLEVGQVVMANYNVDYPRKRGFWYDVEIC
RKRQTRTARELYGNIRLLNDSQLNNCRIMFVDEVLMIELPKERRPLIASPSQPPPALRNT
GKSGPSCRFCKDDENKPCRKCACHVCGGREAPEKQLLCDECDMAFHLYCLKPPLTSVPPE
PEWYCPSCRTDSSEVVQAGEKLKESKKKAKMASATSSSRRDWGKGMACVGRTTECTIVPA
NHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVLAGGYEDDVDNGNY
FTYTGSGGRDLSGNKRTAGQSSDQKLTNNNRALALNCHSPINEKGAEAEDWRQGKPVRVV
RNMKGGKHSKYAPAEGNRYDGIYKVVKYWPERGKSGFLVWRYLLRRDDTEPEPWTREGKD
RTRQLGLTMQYPEGYLEALANKEKSRKRPAKALEQGPSSSKTGKSKQKSTGPTLSSPRAS
KKSKLEPYTLSEQQANLIKEDKGNAKLWDDVLTSLQDGPYQIFLSKVKEAFQCICCQELV
FRPVTTVCQHNVCKDCLDRSFRAQVFSCPACRFELDHSSPTRVNQPLQTILNQLFPGYGS
GR

Sequence of entity 9 (R, r), FASTA

>9W2M_9 Zinc finger BED domain-containing protein 3 (chains R, r)
SYSEAWGYFHLDPAQPRHRMMSAWATCRLCGLQVGGLPNFQMWTRALCQHLSDVH

Sequence of entity 10 (N, n), FASTA

>9W2M_10 NACHT, LRR and PYD domains-containing protein 14 (chains N, n)
IDYRTVIKENIFTMWYKTSLHGEFATLNCVITPKDQNLLQHIFDEDIQTSEAPQTVVLQG
AAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISQVKEKSFAQLISKHWPSSEGPI
EQVLSKPSSLLFIIDSFDELDFSFEEPQFALCKDWTQISPVSFLISSLLRKVMLPESYLL
VATRSTAWKRLVPLLQKPQRVKLSGLSKNARMDYIHHLLKDKAWATSAIYSLRMNWRLFH
MCHVCHMCQMICAVLKGQVEKGGRVEETCKTSTALFTYYICSLFPRIPVGCVTLPNETLL
RSLCKAAVEGIWTMKHVLYQQNLRKHELTREDILLFLDAKVLQQDTEYENCYMFTHLHVQ
EFFAALFYLLRENLEEQDYPSEPFENLYLLLESNHIHDPHLEQMKCFLFGLLNKDRVRQL
EETFNLTISMEVREELLACLEGLEKDDSSLSQLRFQDLLHCIYETQDQEFITQALMYFQK
IIVRVDEEPQLRIYSFCLKHCHTLKTMRLTARADLKNMLDTAEMCLEGAAVQVIHYWQDL
FSVLHTNESLIEMDLYESRLDESLMKILNEELSHPKCKLQKLIFRAVDFLNGCQDFTFLA
SNKKVTHLDLKETDLGVNGLKTLCEALKCKGCKLRVLRLASCDLNVARCQKLSNALQTNR
SLVFLNLSLNNLSNDGVKSLCEVLENPNSSLERLALASCGLTKAGCKVLSSALTKSKRLT
HLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEHLSTALLHNRSLVHLD
LGQNKLADNGVKLLCHSLQQPHCNLQELELMSCVLTSKACGDLASVLVNNSNLWSLDLGH
NILDDAGLNILCDALRNPNCHVQRLGLENCGLTPGCCQDLLGILSNNKSVIQMNLMKNAL
DHESIKNLCKVLRSPTCKMEFLALDKKEILKKKIKKFLVDVRINNPHLVIGPECPNTESG
CWWNYF

Sequence of entity 11 (L, l), FASTA

>9W2M_11 Tubulin beta-2A chain (chains L, l)
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Sequence of entity 12 (M, m), FASTA

>9W2M_12 Tubulin beta-2B chain (chains M, m)
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Ligands and cofactors

ID	Name	Formula	Copies
ADP	Adenosine-5'-diphosphate	C10 H15 N5 O10 P2	4
GDP	Guanosine-5'-diphosphate	C10 H15 N5 O11 P2	4

Primary citation

Molecular basis of oocyte cytoplasmic lattice assembly. Liu, S., Liu, Y., Xue, J. et al. Nature (2026) 654:532-540. DOI 10.1038/s41586-026-10360-7 · PubMed

Other PDB entries of the same protein (UniProt Q8K3V4 (AlphaFold model), which also has an AlphaFold model), best resolution first:

24MC 3.4 Å, Structure of oocyte cytoplasmic lattices
12DL 3.5 Å, Native structure of the cytoplasmic lattice (CPL) asymmetric unit from mouse MII eggs
9XRL 3.74 Å, Structure of mouse cytoplasmic lattice (CPL) repeating unit
9SFP 4.2 Å, Native cytoplasmic lattices from mouse oocytes
9T63 4.7 Å, Asymmetric unit of a cytoplasmic lattice filament repeat unit
9T66 5.3 Å, Complex linking two repeat units of a cytoplasmic lattice filament
9T65 5.6 Å, Complex linking two cytoplasmic lattice filaments
9T64 7.3 Å, Cytoplasmic lattice filament repeat unit with the central FBXW-SKP1 complex
9T67 7.7 Å, Cytoplasmic lattice filament repeat unit with ubiquitin
9T68 8.0 Å, Composite structure of the repeat unit of cytoplasmic lattice filament

Browse structure collections

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