Protein UL141 (UL141) is a 338-residue protein from Human cytomegalovirus. This is its AlphaFold structure prediction, created 3 Sept 2026. UniProt accession: Q6RJQ3.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 65.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 13% |
| 70 to 90 | Confident: backbone generally right | 43% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation. Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus down-regulates their cell surface expression
Interacts with human PVR. Interacts with human TNFRSF10A and TNFRSF10B. Forms a homodimer that engages two TNFRSF10B monomers
Host endoplasmic reticulum membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4I9X | X-ray | 2.1 Å | A/B=32-246 |
| 4JM0 | X-ray | 3.25 Å | A/B=30-279 |
| 9DIX | EM | 3.51 Å | B/E=30-279 |
| 9DIY | EM | 5.36 Å | B=30-279 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.