Inactive protein-arginine deiminase type-6 (PADI6) is a 694-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6TGC4.
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The mean pLDDT of this model is 85.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 55% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:37922900, PubMed:41772195). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos: they are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:37922900, PubMed:41772195). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by…
Homodimer; homodimerizes via a head-to tail mechanism (PubMed:38656308, PubMed:39286527). Structural component of cytoplasmic lattices, at least composed of PADI6, NLRP2, NLRP5, NLRP7, NLRP14, TLE6, KHDC3L and OOEP (PubMed:37148315). Cytoplasmic lattices form a filamentous architecture; the external framework is built from PADI6 decamers and the subcortical maternal complexes (SCMC) (By…
Cytoplasm, Cytoplasmic vesicle, secretory vesicle, Cortical granule, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4DAT | X-ray | 1.4 Å | B=441-449 |
| 8QL0 | X-ray | 1.68 Å | A=2-694 |
| 4DAU | X-ray | 2.0 Å | B=1-13 |
| 9FMN | X-ray | 2.44 Å | A/B=1-694 |
| 9LPK | EM | 3.03 Å | B/C=1-694 |
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