Dynamin-binding protein (DNMBP) is a 1577-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6XZF7.
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The mean pLDDT of this model is 63.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:17015620, PubMed:19767742). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (By similarity)
Binds DNM1 via its N-terminal SH3 domains. The C-terminal SH3 domain binds a complex containing actin, tubulin, Hsp70 and actin-regulatory proteins, such as ENAH, EVL, WIRE, CR16, WAVE1 and NAP1L1 (By similarity). Interacts with FASLG (PubMed:19807924). Interacts (via SH3 domain 6) with WASL (PubMed:17015620, PubMed:19767742, PubMed:24332715). Interacts (via SH3 domain 6) interacts with ENAH…
Cytoplasm, Golgi apparatus, Golgi stack, Cytoplasm, cytoskeleton, Synapse, Cell junction
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4CC2 | X-ray | 1.55 Å | A/C=1513-1577 |
| 4GLM | X-ray | 1.9 Å | A/B/C/D=246-301 |
| 4CC3 | X-ray | 1.97 Å | A/C/E/G=1513-1577 |
| 4CC7 | X-ray | 1.97 Å | A/C/E/G/I/K/M=1513-1577 |
| 4CC4 | X-ray | 2.6 Å | B/D/F=1513-1577 |
| 1UG1 | NMR | A=1278-1355 | |
| 1UHC | NMR | A=1510-1575 |
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