4CC7: Sixth or C-terminal SH3 domain of human Tuba

Crystal structure of the sixth or C-terminal SH3 domain of human Tuba in complex with proline-rich peptides of N-WASP. Space group P41. Determined by X-ray diffraction at 1.97 Å resolution. Released 30 Oct 2013.

Method: X-ray diffraction
Resolution: 1.97 Å
Organism: HOMO SAPIENS
Chains: 14
Atoms: 4,418
Mol. weight: 62.55 kDa
Ligands: MG
Released: 30 Oct 2013

Explore 4CC7 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

4CC7 contains 15 α-helices and 56 β-strands across 14 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chains A, C, E, G and I: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	1517-1520	4	1
β-strand	1524	1	2
β-strand	1531	1	1
β-strand	1534	1	2
β-strand	1539-1544	6	1
β-strand	1554-1559	6	1
β-strand	1562-1567	6	1
α-helix	1568-1570	3
β-strand	1571-1572	2	1

Chains B and L: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	3-6	4

Chains D, F, J and N: 1 helix, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-6	5

Chain H: 2 helices, 0 β-strands

Element	Residues	Length	Sheet
α-helix	2-6	5
α-helix	9-11	3

Chains K and M: 1 helix, 8 β-strands

Element	Residues	Length	Sheet
β-strand	1517-1520	4	11
β-strand	1524	1	12
β-strand	1531	1	11
β-strand	1534	1	12
β-strand	1539-1544	6	11
β-strand	1554-1559	6	11
β-strand	1562-1567	6	11
α-helix	1568-1570	3
β-strand	1571-1573	3	11

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Dynamin-binding protein	A, C, E, G, I, K, M	protein	67	HOMO SAPIENS	Q6XZF7 (AlphaFold model)
Neural wiskott-aldrich syndrome protein	B, D, F, H, J, L, N	protein	12	HOMO SAPIENS	O00401 (AlphaFold model)

Sequence of entity 1 (A, C, E, G, I, K, M), FASTA

>4CC7_1 DYNAMIN-BINDING PROTEIN (chains A, C, E, G, I, K, M)
GPEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNY
IRKTEYT

Sequence of entity 2 (B, D, F, H, J, L, N), FASTA

>4CC7_2 NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN (chains B, D, F, H, J, L, N)
PPPALPSSAPSG

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	2

Water and common crystallization additives (CL, GOL) are not listed.

Primary citation

Structural Details of Human Tuba Recruitment by Inlc of Listeria Monocytogenes Elucidate Bacterial Cell-Cell Spreading. Polle, L., Rigano, L.A., Julian, R. et al. Structure (2014) 22:304. DOI 10.1016/J.STR.2013.10.017 · PubMed

Other PDB entries of the same protein (UniProt Q6XZF7 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4CC2 1.55 Å, Complex of human Tuba C-terminal SH3 domain with human N-WASP proline- rich peptide -…
4GLM 1.9 Å, Crystal structure of the SH3 Domain of DNMBP protein [Homo sapiens]
4CC3 1.97 Å, Complex of human Tuba C-terminal SH3 domain and Mena proline-rich peptide - H3
4CC4 2.6 Å, Complex of InlC of Listeria monocytogenes and human Tuba C-terminal SH3 domain
1UG1 SH3 domain of Hypothetical protein BAA76854.1
1UHC Solution Structure of RSGI RUH-002, a SH3 Domain of KIAA1010 protein [Homo sapiens]

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