Protein PEAK3 (PEAK3) is a 473-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6ZS72.
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The mean pLDDT of this model is 77.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Probable catalytically inactive kinase (Probable). Interacts with CRK-II and antagonizes CRK-II-signaling. Prevents the formation of CRK-II-dependent membrane ruffling and lamellipodia-like extensions (PubMed:31311869)
Homodimerizes (PubMed:31311869). Interacts with CRK isoform CRK-II; the interaction requires PEAK3 homodimerization (PubMed:31311869)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8DGO | X-ray | 2.3 Å | C=23-29 |
| 8DGP | X-ray | 2.7 Å | E/F/G/H=54-74 |
| 8DP5 | EM | 3.1 Å | A/B/E/P=1-473 |
| 8DS6 | EM | 4.9 Å | A/B=1-473 |
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