Whirlin (Whrn) is a 918-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q80VW5.
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The mean pLDDT of this model is 58.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 8% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 48% |
What pLDDT means and how to read it
Involved in hearing and vision as member of the USH2 complex (PubMed:20502675). Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear (PubMed:15590699). Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear (PubMed:20502675, PubMed:24334608). In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport (PubMed:20502675)
Forms homooligomers (PubMed:15590698, PubMed:25406310). Interacts (via C-terminal PDZ domain) with MYO15A; this interaction is necessary for localization of WHRN to stereocilia tips (PubMed:15590698, PubMed:15654330). Interacts (via C-terminal PDZ domain) with MPP1/p55 (PubMed:16829577, PubMed:17584769). Interacts with LRRC4C/NGL1 (PubMed:15590698). Interacts with MYO7A (PubMed:15590698).…
Cytoplasm, Cell projection, stereocilium, Cell projection, growth cone, Photoreceptor inner segment, Synapse
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6Y9Q | X-ray | 1.31 Å | B=821-918 |
| 6Y9O | X-ray | 1.63 Å | A=821-918 |
| 6Y38 | X-ray | 1.7 Å | A/B=821-915 |
| 6FDD | X-ray | 1.75 Å | A/B/C/D/E/F=420-499 |
| 6FDE | X-ray | 1.85 Å | A=420-499 |
| 6Y9N | X-ray | 1.93 Å | A=821-918 |
| 6Y9P | X-ray | 3.17 Å | A/B/E/G/I/K=821-918 |
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