LIM domain-binding protein 1 (LDB1) is a 411-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86U70.
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The mean pLDDT of this model is 70.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state
Interacts with ESR1 (PubMed:19117995). Forms homodimers and heterodimers. Interacts with and activates LHX1/LIM1. Interacts with the LIM domains of ISL1 and LMO2. Can assemble in a complex with LMO2 and TAL1/SCL but does not interact with TAL1/SCL directly. Strongly interacts with the LIM2 domain of LMX1A and more weakly with the LIM1 domain. Homodimerization is not required for, and does not…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7OB5 | X-ray | 1.8 Å | P=401-411 |
| 7OB8 | X-ray | 1.8 Å | B=401-411 |
| 9F5B | X-ray | 1.8 Å | A=336-375 |
| 2XJY | X-ray | 2.4 Å | B=334-368 |
| 8HIB | X-ray | 2.45 Å | V=56-285 |
| 2XJZ | X-ray | 2.8 Å | I/J/K/L/M=334-368 |
| 2YPA | X-ray | 2.8 Å | D=336-375 |
| 6TYD | X-ray | 2.8 Å | V=56-285 |
| 8SSU | X-ray | 2.89 Å | A=231-294 |
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