Stimulator of interferon genes protein (STING1) is a 379-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86WV6.
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The mean pLDDT of this model is 83.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 33% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 8% |
What pLDDT means and how to read it
Key innate immune signaling adapter that promotes the production of type I interferon (IFN-alpha and IFN-beta) in response to the presence of DNA from bacteria and viruses in the cytosol (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23747010, PubMed:23910378, PubMed:25704810, PubMed:27801882, PubMed:29973723, PubMed:30842659, PubMed:31992625, PubMed:32926474, PubMed:35045565, PubMed:35388221, PubMed:36808561, PubMed:37086726, PubMed:37832545, PubMed:39255680, PubMed:39947179). Innate immune response is triggered by non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm, which induces production of cyclic dinucleotides…
Homodimer; forms a homodimer in absence of cyclic nucleotide (c-di-GMP or cGAMP); 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization (PubMed:19285439, PubMed:40498864, PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728659, PubMed:22728660, PubMed:30842659, PubMed:40610719, PubMed:41865946). Homotetramer; in presence of cyclic nucleotide (c-di-GMP or cGAMP),…
Endoplasmic reticulum-Golgi intermediate compartment membrane, Endoplasmic reticulum membrane, Cytoplasm, perinuclear region, Golgi apparatus membrane, Golgi apparatus, trans-Golgi network membrane, Cytoplasmic vesicle, autophagosome membrane, Endosome membrane, Lysosome membrane, Mitochondrion…
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6MX3 | X-ray | 1.36 Å | A/B=155-341 |
| 4EMT | X-ray | 1.5 Å | A/B=155-341 |
| 6UKZ | X-ray | 1.52 Å | A/B=155-341 |
| 9CUD | X-ray | 1.53 Å | A/B=155-341 |
| 6UKU | X-ray | 1.68 Å | A=155-341 |
| 7ZKU | X-ray | 1.7 Å | A/B=140-343 |
| 8STI | X-ray | 1.72 Å | A=153-339 |
| 6MX0 | X-ray | 1.73 Å | A/B=155-341 |
| 6UKM | X-ray | 1.74 Å | A=155-341 |
| 6UL0 | X-ray | 1.76 Å | A=155-341 |
| 6XNP | X-ray | 1.77 Å | A/B=155-341 |
| 7KW1 | X-ray | 1.8 Å | A=140-379 |
| 9IJN | X-ray | 1.81 Å | A=154-341 |
| 6UKV | X-ray | 1.83 Å | A/B=155-341 |
| 9CUB | X-ray | 1.87 Å | A/B=155-341 |
| 4KSY | X-ray | 1.88 Å | A=138-379 |
| 4QXO | X-ray | 1.88 Å | A=155-341 |
| 4LOI | X-ray | 1.89 Å | A/B=155-341 |
| 8A2K | X-ray | 1.89 Å | A/B=140-379 |
| 9KYA | X-ray | 1.89 Å | A=155-341 |
Showing 20 of 115 experimental structures (best resolution first).
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