STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 6. Determined by X-ray diffraction at 1.52 Å resolution. Released 19 Aug 2020.
Explore 6UKZ in 3D Show helices and sheets RCSB PDB PDBe
6UKZ contains 25 α-helices and 14 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 155-163 | 9 | |
| α-helix | 164-168 | 5 | |
| α-helix | 169-185 | 17 | |
| α-helix | 193-195 | 3 | |
| β-strand | 198-203 | 6 | 1 |
| α-helix | 212-215 | 4 | |
| β-strand | 219-224 | 6 | 1 |
| α-helix | 225-227 | 3 | |
| β-strand | 228-232 | 5 | 2 |
| β-strand | 235-240 | 6 | 2 |
| β-strand | 243-249 | 7 | 1 |
| β-strand | 252-261 | 10 | 1 |
| α-helix | 264-273 | 10 | |
| α-helix | 275-277 | 3 | |
| α-helix | 281-283 | 3 | |
| α-helix | 284-299 | 16 | |
| α-helix | 303-307 | 5 | |
| β-strand | 309-314 | 6 | 1 |
| α-helix | 325-334 | 10 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 155-163 | 9 | |
| α-helix | 164-168 | 5 | |
| α-helix | 169-181 | 13 | |
| α-helix | 182-186 | 5 | |
| α-helix | 192-195 | 4 | |
| β-strand | 198-203 | 6 | 3 |
| α-helix | 212-215 | 4 | |
| β-strand | 219-224 | 6 | 3 |
| α-helix | 225-227 | 3 | |
| β-strand | 228-232 | 5 | 4 |
| β-strand | 235-240 | 6 | 4 |
| β-strand | 243-249 | 7 | 3 |
| β-strand | 252-261 | 10 | 3 |
| α-helix | 264-273 | 10 | |
| α-helix | 275-277 | 3 | |
| α-helix | 281-283 | 3 | |
| α-helix | 284-299 | 16 | |
| α-helix | 303-306 | 4 | |
| β-strand | 309-314 | 6 | 3 |
| α-helix | 325-334 | 10 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | A, B | protein | 300 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Homo sapiens | Q12306 (AlphaFold model), Q86WV6 (AlphaFold model) |
>6UKZ_1 fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain (chains A, B) MAHHHHHHGSDSEVNQEAKPEVKPEVKPETHINLKVSDGSSEIFFKIKKTTPLRRLMEAF AKRQGKEMDSLTFLYDGIEIQADQTPEDLDMEDNDIIEAHREQIGGENLYFQSVAHGLAW SYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRF LDKLPQQTADRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSR EDRLEQAKLFCQTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEV
| ID | Name | Formula | Copies |
|---|---|---|---|
| QBG | 4-[5-(2-{[2-(3-carboxypropanoyl)-4-fluoro-6-methoxy-1-benzothiophen-5-yl]oxy}et… | C28 H25 F O10 S2 | 1 |
An orally available non-nucleotide STING agonist with antitumor activity. Pan, B.S., Perera, S.A., Piesvaux, J.A. et al. Science (2020) 369. DOI 10.1126/science.aba6098 · PubMed
Other PDB entries of the same protein (UniProt Q12306 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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