PHD finger protein 13 (PHF13) is a 300-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q86YI8.
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The mean pLDDT of this model is 64.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 21% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 37% |
| Below 50 | Very low: often disordered regions | 29% |
What pLDDT means and how to read it
Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response (PubMed:19638409). Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1 (PubMed:23034801). Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis (PubMed:19638409). Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation (PubMed:23034801). Essential for testicular stem-cell differentiation and sustained…
Interacts with histone H3 that is trimethylated at 'Lys-4' (H3K4me3) (PubMed:23034801, Ref.10). Interacts with GSK3B (PubMed:19638409). Interacts with TRIM28 (PubMed:23034801). Interacts with SETDB1; the interaction probably enhances SETDB1 chromatin-associated levels and activity (PubMed:23034801)
Nucleus, Nucleus, nucleoplasm
Compare the prediction with experimentally determined structures of the same protein:
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