Myosin essential light chain ELC (PF3D7_1017500) is a 134-residue protein from Plasmodium falciparum (isolate 3D7). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IJM4.
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The mean pLDDT of this model is 88.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 41% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Light chain of myosin MyoA (PubMed:28893907, PubMed:33046215, PubMed:37308472). Enhances MyoA-dependent actin motility (PubMed:28893907). Required for parasite invasion into host red blood cells; plays a role in host erythrocyte deformation and internalization during merozoite invasion (PubMed:33046215, PubMed:33104759)
Crystallizes as a dimer covalently linked via a disulfide bridge; however, exists as a monomer in solution (PubMed:33051581). Component of a complex, composed at least of MyoA, MTIP and ELC; the presence of MTIP bound to MyoA is a prerequisite for ELC binding (PubMed:33046215, PubMed:33051581)
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6TJ4 | X-ray | 1.5 Å | A/B=1-74 |
| 8A12 | X-ray | 2.03 Å | E=1-134 |
| 8CDQ | X-ray | 2.21 Å | C=1-134 |
| 8CDM | X-ray | 2.35 Å | E=1-134 |
| 6ZN3 | X-ray | 2.51 Å | A/D/G/J/M=1-134 |
| 6YCY | X-ray | 2.55 Å | E=1-134 |
| 6YCZ | X-ray | 3.27 Å | C=1-134 |
| 6YCX | X-ray | 3.99 Å | F/G=1-134 |
| 6TJ3 | NMR | A=1-74 |
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