Humanin (MT-RNR2) is a 24-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IVG9.
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The mean pLDDT of this model is 72.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 58% |
| 50 to 70 | Low: treat with caution | 38% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Plays a role as a neuroprotective factor (PubMed:11371646, PubMed:11717357, PubMed:12154011, PubMed:12787071, PubMed:12860203, PubMed:19386761). Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease (PubMed:11371646, PubMed:11717357, PubMed:12154011, PubMed:12787071, PubMed:12860203, PubMed:19386761). Mediates its neuroprotective effect by binding to the humanin receptor complex; binding of MT-RNR2 activates the intracellular JAK-STAT3 signaling pathways (PubMed:16005025, PubMed:19386761, PubMed:27384491). Also acts as a ligand for G protein-coupled receptors FPR2/FPRL1 and FPR3/FPRL2…
Homodimer (PubMed:12787071, PubMed:12860203). Interacts with amyloid-beta protein 42 (Abeta42); the interaction prevents Abeta42 fibril formation (PubMed:28282805). Interacts with BAX; forms fibers with BAX which results in BAX conformational changes and sequestering of BAX into the fibers, preventing BAX activation (PubMed:12732850, PubMed:31690630). Interacts with both full-length BID and…
Secreted, Cytoplasm, Cell projection, cilium, flagellum, Nucleus, Mitochondrion
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