Aprataxin and PNK-like factor (APLF) is a 511-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8IW19.
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The mean pLDDT of this model is 61.5 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 23% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 49% |
What pLDDT means and how to read it
Histone chaperone involved in single-strand and double-strand DNA break repair (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:21211722, PubMed:29905837, PubMed:30104678). Recruited to sites of DNA damage through interaction with branched poly-ADP-ribose chains, a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions (PubMed:17353262, PubMed:17396150, PubMed:21211721, PubMed:30104678). Following recruitment to DNA damage sites, acts as a histone chaperone that mediates histone eviction during DNA repair and promotes recruitment of histone variant MACROH2A1 (PubMed:21211722,…
Interacts with LIG4 (PubMed:17396150). Interacts with PARP1 (PubMed:17353262, PubMed:17396150). Interacts with XRCC4 (PubMed:17353262, PubMed:17396150, PubMed:18077224). Interacts (via KBM motif) with XRCC5 and XRCC6; promoting recruitment to DNA damage sites (PubMed:23689425, PubMed:31733588). Interacts with XRCC1 (PubMed:17353262, PubMed:17507382). Interacts (via C-terminal disordered region)…
Nucleus, Chromosome, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5W7W | X-ray | 1.35 Å | A/T=1-105 |
| 5E50 | X-ray | 1.38 Å | A/B=1-105 |
| 6TYZ | X-ray | 1.51 Å | B=179-194 |
| 6TYW | X-ray | 1.7 Å | B=179-194 |
| 5W7X | X-ray | 2.0 Å | A/B/C/D=1-105 |
| 5W7Y | X-ray | 2.1 Å | A/B=1-105 |
| 6YN1 | X-ray | 2.35 Å | E/J/O/T/Y/d/i/n=449-490 |
| 6TYT | X-ray | 2.4 Å | C=179-194 |
| 6ERF | X-ray | 3.01 Å | Q/R/S/T=174-191 |
| 2KQB | NMR | A=368-451 | |
| 2KQC | NMR | A=368-451 | |
| 2KQD | NMR | A=368-451 | |
| 2KQE | NMR | A=368-451 | |
| 2KUO | NMR | A=360-448 |
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