Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (CMTR1) is a 835-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8N1G2.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 71% |
| 70 to 90 | Confident: backbone generally right | 15% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway
Interacts with POLR2A (via C-terminus)
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4N49 | X-ray | 1.9 Å | A=126-550 |
| 4N4A | X-ray | 2.35 Å | A=126-550 |
| 4N48 | X-ray | 2.7 Å | A/B=126-550 |
| 8P4E | EM | 3.9 Å | O=1-835 |
| 8P4F | EM | 4.0 Å | O=1-835 |
| 8W8F | EM | 4.0 Å | b=1-835 |
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