8W8F: MRNA-capping enzyme

Name: PDB 8W8F: human co-transcriptional RNA capping enzyme RNGTT-CMTR1
Published: 2024-04-10
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

human co-transcriptional RNA capping enzyme RNGTT-CMTR1. Determined by electron microscopy at 4.0 Å resolution. Released 10 Apr 2024.

Method: Electron microscopy
Resolution: 4.0 Å
Organisms: Homo sapiens, Sus scrofa
Chains: 19
Atoms: 46,667
Mol. weight: 851.91 kDa
Ligands: MG, ZN, GTP
Released: 10 Apr 2024

Explore 8W8F in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

8W8F contains 259 α-helices and 321 β-strands across 16 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 25 helices, 29 β-strands

Element	Residues	Length	Sheet
α-helix	6-7	2
β-strand	16	1	1
β-strand	20	1	1
β-strand	24-28	5	1
α-helix	29-30	2
α-helix	33-35	3
α-helix	41-43	3
α-helix	47-56	10
β-strand	61-66	6	1
α-helix	77-80	4
β-strand	85-88	4	1
α-helix	96-99	4
α-helix	100-110	11
β-strand	121-126	6	1
α-helix	131-145	15
α-helix	149-159	11
α-helix	167-177	11
α-helix	180-182	3
α-helix	183-190	8
α-helix	191-194	4
β-strand	241-243	3	2
α-helix	247-261	15
β-strand	271-275	5	3
α-helix	281-285	5
β-strand	289-295	7	3
β-strand	298-304	7	2
β-strand	310-313	4	2
β-strand	319-322	4	2
β-strand	328	1	4
β-strand	336	1	4
β-strand	340-351	12	2
β-strand	354-366	13	2
β-strand	367	1	5
β-strand	370	1	5
α-helix	372-374	3
α-helix	377-384	8
α-helix	385-389	5
α-helix	390-394	5
β-strand	409-412	4	2
β-strand	416-417	2	3
α-helix	418-424	7
β-strand	437-444	8	3
β-strand	451-459	9	3
α-helix	462-464	3
β-strand	466-474	9	6
β-strand	486-490	5	6
β-strand	492	1	7
β-strand	499-500	2	6
α-helix	505-508	4
β-strand	514-520	7	6
β-strand	523-529	7	6
β-strand	538	1	7
α-helix	539-550	12
α-helix	555-563	9

Chain A: 76 helices, 66 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	15
β-strand	20-25	6	16
α-helix	26-27	2
α-helix	28-34	7
β-strand	47	1	17
β-strand	52	1	17
α-helix	53	1
β-strand	86-88	3	18
β-strand	94-95	2	19
α-helix	100-109	10
α-helix	124-132	9
α-helix	137-147	11
β-strand	192-194	3	20
β-strand	197-200	4	20
β-strand	214-215	2	20
α-helix	216-217	2
α-helix	218-225	8
α-helix	230-235	6
α-helix	245-247	3
β-strand	249-250	2	19
β-strand	253-255	3	18
α-helix	256	1
α-helix	275-292	18
α-helix	293-297	5
α-helix	302-318	17
α-helix	326-328	3
β-strand	329	1	21
α-helix	334	1
β-strand	335	1	21
α-helix	336-337	2
α-helix	339-344	6
α-helix	350-355	6
β-strand	357-359	3	22
β-strand	362-369	8	23
β-strand	377-380	4	23
α-helix	382-385	4
β-strand	389-393	5	24
α-helix	394	1
α-helix	399-408	10
β-strand	416-420	5	24
β-strand	426-428	3	24
α-helix	435-438	4
β-strand	445-449	5	24
α-helix	450	1
β-strand	455-459	5	23
α-helix	466-468	3
β-strand	469-476	8	23
β-strand	482-484	3	23
α-helix	489-492	4
β-strand	500-504	5	23
α-helix	509-518	10
β-strand	520	1	23
α-helix	521-524	4
β-strand	526-527	2	25
β-strand	532-533	2	25
α-helix	539-548	10
β-strand	554-555	2	26
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	27
α-helix	576-577	2
β-strand	579	1	28
β-strand	585	1	28
β-strand	586-587	2	26
α-helix	588-595	8
β-strand	602-605	4	29
β-strand	627-631	5	29
β-strand	634-637	4	29
α-helix	642-645	4
α-helix	652-659	8
α-helix	663-683	21
β-strand	685-686	2	30
α-helix	689-692	4
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-756	24
α-helix	765-772	8
α-helix	778-785	8
β-strand	789-790	2	31
β-strand	793	1	32
β-strand	796	1	32
α-helix	811	1
β-strand	822-823	2	31
α-helix	833-867	35
β-strand	872-873	2	33
β-strand	879-880	2	33
β-strand	886-888	3	33
α-helix	891-893	3
β-strand	896	1	34
β-strand	902-905	4	35
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	36
α-helix	936-944	9
α-helix	947-969	23
β-strand	976-979	4	35
α-helix	983-994	12
α-helix	1001	1
β-strand	1002	1	36
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1053	3
α-helix	1054-1058	5
α-helix	1062-1078	17
β-strand	1080	1	34
α-helix	1081-1082	2
α-helix	1087-1101	15
α-helix	1121-1128	8
β-strand	1139-1140	2	37
β-strand	1142	1	38
β-strand	1143	1	39
α-helix	1146-1149	4
α-helix	1151-1161	11
β-strand	1164	1	40
β-strand	1170-1177	8	41
α-helix	1192-1196	5
β-strand	1210-1216	7	41
α-helix	1218-1223	6
α-helix	1228-1239	12
β-strand	1243-1246	4	41
β-strand	1255-1261	7	41
α-helix	1283-1294	12
β-strand	1299	1	40
β-strand	1308-1310	3	38
β-strand	1319-1322	4	42
β-strand	1328-1331	4	42
β-strand	1335-1337	3	38
β-strand	1352	1	39
β-strand	1358-1359	2	37
α-helix	1362-1368	7
α-helix	1372-1387	16
α-helix	1395-1404	10
α-helix	1416-1419	4
α-helix	1426-1430	5
α-helix	1436-1444	9
β-strand	1448-1449	2	16
α-helix	1455-1460	6
β-strand	1472-1475	4	43
α-helix	1479-1482	4
α-helix	1483-1486	4

Chain b: 36 helices, 31 β-strands

Element	Residues	Length	Sheet
α-helix	147-149	3
α-helix	158-161	4
α-helix	164-166	3
α-helix	170-173	4
β-strand	176-179	4	8
α-helix	193-204	12
α-helix	205-207	3
α-helix	211-221	11
α-helix	225-227	3
α-helix	235-246	12
β-strand	255	1	9
β-strand	261	1	9
β-strand	271-276	6	10
α-helix	282-291	10
α-helix	292-294	3
β-strand	295-300	6	10
α-helix	310-312	3
β-strand	321-323	3	10
α-helix	329-331	3
α-helix	339-351	13
β-strand	358-363	6	10
α-helix	373-375	3
α-helix	376-379	4
α-helix	381-394	14
β-strand	395-405	11	10
α-helix	411-423	13
β-strand	424-430	7	10
β-strand	442-449	8	10
α-helix	450	1
α-helix	454-469	16
β-strand	475-479	5	8
α-helix	483-488	6
α-helix	490-519	30
α-helix	528-539	12
α-helix	554-562	9
α-helix	567-571	5
α-helix	572-574	3
β-strand	575-576	2	11
α-helix	582-585	4
β-strand	591-596	6	11
β-strand	600-605	6	12
β-strand	611-614	4	12
α-helix	620-622	3
β-strand	623-624	2	12
β-strand	635-646	12	12
α-helix	649-651	3
β-strand	653-666	14	12
β-strand	669-670	2	12
α-helix	676-689	14
β-strand	701-703	3	12
α-helix	704-706	3
β-strand	707-708	2	11
α-helix	709-711	3
α-helix	713-716	4
β-strand	719-723	5	12
β-strand	731-736	6	12
β-strand	742-743	2	12
β-strand	747-752	6	11
β-strand	754	1	13
β-strand	758-763	6	14
β-strand	768-773	6	14
β-strand	779-780	2	14
α-helix	785-787	3
β-strand	788	1	13
α-helix	791-796	6
β-strand	799-802	4	11
α-helix	823-832	10

Chain B: 48 helices, 75 β-strands

Element	Residues	Length	Sheet
α-helix	22-36	15
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-64	2
β-strand	65-67	3	44
β-strand	84-93	10	44
β-strand	97-98	2	45
β-strand	106-107	2	45
α-helix	110-115	6
β-strand	121-131	11	44
β-strand	141-153	13	44
β-strand	155	1	46
α-helix	168-173	6
β-strand	185-187	3	46
β-strand	190-194	5	46
β-strand	196-200	5	47
α-helix	201	1
β-strand	205-208	4	48
β-strand	215-223	9	48
β-strand	233-240	8	48
β-strand	256-259	4	48
β-strand	263	1	49
β-strand	267-268	2	48
α-helix	269-275	7
α-helix	281-288	8
α-helix	295-305	11
α-helix	314-322	9
β-strand	325	1	49
α-helix	336-345	10
α-helix	358-377	20
α-helix	381-384	4
β-strand	391-394	4	47
α-helix	396-423	28
α-helix	431-434	4
α-helix	438-449	12
β-strand	467-469	3	46
α-helix	470	1
α-helix	475-482	8
β-strand	484-486	3	47
α-helix	503-505	3
β-strand	509	1	50
β-strand	523-525	3	47
β-strand	526	1	50
β-strand	531-532	2	51
α-helix	539-547	9
β-strand	550-552	3	52
α-helix	553-555	3
β-strand	565-569	5	52
β-strand	572-577	6	52
α-helix	584-591	8
β-strand	602-606	5	52
β-strand	611-615	5	52
β-strand	621-627	7	51
β-strand	628-629	2	53
β-strand	632-633	2	53
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	51
α-helix	667-670	4
β-strand	675-676	2	51
α-helix	679-682	4
β-strand	695-696	2	51
α-helix	700-703	4
α-helix	719-729	11
β-strand	732	1	54
β-strand	748-751	4	55
β-strand	755	1	56
β-strand	759-760	2	57
α-helix	764-767	4
β-strand	776-782	7	58
β-strand	783-784	2	30
β-strand	793-797	5	58
α-helix	798-802	5
β-strand	808-817	10	55
β-strand	827-829	3	59
β-strand	837-838	2	59
β-strand	848	1	60
β-strand	853	1	61
β-strand	854	1	60
α-helix	855	1
β-strand	859-860	2	55
β-strand	865-867	3	61
β-strand	869-871	3	59
α-helix	874-876	3
β-strand	888-891	4	59
β-strand	894-895	2	61
α-helix	896-897	2
β-strand	902-911	10	55
β-strand	917-927	11	55
β-strand	934-936	3	58
β-strand	942-949	8	58
β-strand	956	1	62
β-strand	965-967	3	58
α-helix	971-975	5
α-helix	978-993	16
β-strand	997-998	2	57
α-helix	1008-1016	9
β-strand	1025-1026	2	58
α-helix	1028	1
β-strand	1029	1	62
α-helix	1030	1
α-helix	1035	1
β-strand	1036	1	62
α-helix	1037	1
β-strand	1041-1050	10	58
β-strand	1051	1	54
β-strand	1060-1062	3	23
β-strand	1067	1	63
β-strand	1074	1	63
α-helix	1082-1083	2
β-strand	1084-1086	3	22
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	15
β-strand	1125	1	15
α-helix	1126	1
β-strand	1127-1129	3	64
β-strand	1134-1136	3	64
β-strand	1146-1150	5	15
α-helix	1153-1164	12
β-strand	1167-1172	6	16

Chain C: 12 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	65
β-strand	18-24	7	65
α-helix	28-36	9
α-helix	37-41	5
β-strand	44-55	12	66
α-helix	61-69	9
β-strand	73	1	67
α-helix	82-84	3
α-helix	85-87	3
β-strand	99-106	8	66
β-strand	113-116	4	68
α-helix	117-119	3
β-strand	121-122	2	66
β-strand	129	1	67
α-helix	145-148	4
β-strand	149-153	5	68
β-strand	158-168	11	66
α-helix	174-176	3
β-strand	179-185	7	65
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	65
α-helix	241-270	30

Chain D: 10 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	69
α-helix	17-19	3
β-strand	21	1	69
α-helix	25-27	3
α-helix	29	1
β-strand	30-31	2	43
α-helix	34-49	16
α-helix	59-70	12
α-helix	77-88	12
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14

Chain E: 11 helices, 12 β-strands

Element	Residues	Length	Sheet
α-helix	4-24	21
β-strand	26	1	70
α-helix	30-33	4
α-helix	37-44	8
β-strand	63	1	71
β-strand	64	1	70
β-strand	71	1	71
β-strand	75	1	72
α-helix	84-96	13
β-strand	102-105	4	72
α-helix	109-111	3
α-helix	112-119	8
β-strand	127-130	4	72
α-helix	133-135	3
α-helix	139-141	3
β-strand	147-150	4	73
α-helix	151-152	2
α-helix	153-163	11
β-strand	172-173	2	74
α-helix	178-183	6
β-strand	191-197	7	73
β-strand	201-207	7	73
β-strand	208-209	2	74

Chain F: 5 helices, 4 β-strands

Element	Residues	Length	Sheet
β-strand	56	1	75
α-helix	57-58	2
α-helix	59-74	16
α-helix	77-79	3
α-helix	89-99	11
β-strand	104-109	6	43
β-strand	115-119	5	43
β-strand	124	1	75
α-helix	125	1

8 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
mRNA-capping enzyme	a	protein	597	Homo sapiens	O60942 (AlphaFold model)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1	b	protein	835	Homo sapiens	Q8N1G2 (AlphaFold model)
DNA-directed RNA polymerase subunit	A	protein	1970	Sus scrofa	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1174	Sus scrofa	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	271	Sus scrofa	I3LCH3
DNA-directed RNA polymerase II subunit RPB4	D	protein	142	Sus scrofa	A0A4X1VM56
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa	I3LSI7
DNA-directed RNA polymerase II subunit F	F	protein	127	Sus scrofa	A0A4X1VEK9
DNA-directed RNA polymerase II subunit RPB7	G	protein	172	Sus scrofa	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa	A0A8W4F9W9

7 more molecules are not listed.

Sequence of entity 1 (a), FASTA

>8W8F_1 mRNA-capping enzyme (chains a)
MAHNKIPPRWLNCPRRGQPVAGRFLPLKTMLGPRYDSQVAEENRFHPSMLSNYLKSLKVK
MGLLVDLTNTSRFYDRNDIEKEGIKYIKLQCKGHGECPTTENTETFIRLCERFNERNPPE
LIGVHCTHGFNRTGFLICAFLVEKMDWSIEAAVATFAQARPPGIYKGDYLKELFRRYGDI
EEAPPPPLLPDWCFEDDEDEDEDEDGKKESEPGSSASFGKRRKERLKLGAIFLEGVTVKG
VTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPVSMDKQNIKLLDLKPYKVSWKADGTRY
MMLIDGTNEVFMIDRDNSVFHVSNLEFPFRKDLRMHLSNTLLDGEMIIDRVNGQAVPRYL
IYDIIKFNSQPVGDCDFNVRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRNKPFFDICT
SRKLLEGNFAKEVSHEMDGLIFQPTGKYKPGRCDDILKWKPPSLNSVDFRLKITRMGGEG
LLPQNVGLLYVGGYERPFAQIKVTKELKQYDNKIIECKFENNSWVFMRQRTDKSFPNAYN
TAMAVCNSISNPVTKEMLFEFIDRCTAASQGQKRKHHLDPDTELMPPPPPKRPRPLT

Sequence of entity 2 (b), FASTA

>8W8F_2 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (chains b)
MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGK
QHSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEAS
SQKGRRGLGLTLRGFDQELNVDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR
KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKM
ANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGM
TLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHF
LMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLL
YCCFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLV
VPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWG
IPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQ
KFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHI
LDVLVLNGTDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLE
MKIIKGSSGTPKLSYTGRDDRHFVPMGLYIVRTVNEPWTMGFSKSFKKKFFYNKKTKDST
FDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKEDVLSFIQMHRA

Sequence of entity 3 (A), FASTA

>8W8F_3 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 4 (B), FASTA

>8W8F_4 DNA-directed RNA polymerase subunit beta (chains B)
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 5 (C), FASTA

>8W8F_5 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDV

Sequence of entity 6 (D), FASTA

>8W8F_6 DNA-directed RNA polymerase II subunit RPB4 (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 7 (E), FASTA

>8W8F_7 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 8 (F), FASTA

>8W8F_8 DNA-directed RNA polymerase II subunit F (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 9 (G), FASTA

>8W8F_9 DNA-directed RNA polymerase II subunit RPB7 (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 10 (H), FASTA

>8W8F_10 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 11 (I), FASTA

>8W8F_11 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 12 (J), FASTA

>8W8F_12 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Ligands and cofactors

ID	Name	Formula	Copies
MG	Magnesium ion	Mg	1
ZN	Zinc ion	Zn	8
GTP	Guanosine-5'-triphosphate	C10 H16 N5 O14 P3	1

Primary citation

Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Li, Y., Wang, Q., Xu, Y. et al. Nat Commun (2024) 15:4622-4622. DOI 10.1038/s41467-024-48963-1 · PubMed

Other PDB entries of the same protein (UniProt O60942 (AlphaFold model), which also has an AlphaFold model), best resolution first:

2C46 1.6 Å, CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
3S24 3.01 Å, Crystal structure of human mRNA guanylyltransferase
8P4B 3.2 Å, Structural insights into human co-transcriptional capping - structure 2
8P4A 3.6 Å, Structural insights into human co-transcriptional capping - structure 1
8P4D 3.6 Å, Structural insights into human co-transcriptional capping - structure 4
8P4C 3.8 Å, Structural insights into human co-transcriptional capping - structure 3
8P4E 3.9 Å, Structural insights into human co-transcriptional capping - structure 5
8W8E 3.9 Å, human co-transcriptional RNA capping enzyme RNGTT

Browse structure collections

About this viewer

MolViewer shows 8W8F directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.