Small vasohibin-binding protein (SVBP) is a 66-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8N300.
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The mean pLDDT of this model is 85.1 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin (PubMed:29146869, PubMed:31171830, PubMed:31235910, PubMed:31235911, PubMed:31270470, PubMed:31324789). This activity is critical for spindle function and accurate chromosome segregation during mitosis since microtubule detyrosination regulates mitotic spindle length and postioning (PubMed:31171830). Also required to enhance the solubility and secretion of VASH1 and VASH2 (PubMed:20736312, PubMed:27879017, PubMed:30607023). Plays a role in axon and excitatory synapse formation (PubMed:31235911)
Interacts with VASH1 and VASH2
Cytoplasm, Secreted, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6J4P | X-ray | 1.6 Å | B=1-66 |
| 6J7B | X-ray | 1.62 Å | B=1-52 |
| 6OCG | X-ray | 1.83 Å | B=26-51 |
| 6J8O | X-ray | 1.85 Å | A=3-49 |
| 6J8N | X-ray | 1.95 Å | A/C=1-66 |
| 6J4U | X-ray | 2.0 Å | B=1-66 |
| 6OCH | X-ray | 2.0 Å | B/D=25-52 |
| 6QBY | X-ray | 2.09 Å | B/D=1-66 |
| 6J4V | X-ray | 2.1 Å | B=1-66 |
| 6NVQ | X-ray | 2.1 Å | B=1-66 |
| 6OCF | X-ray | 2.1 Å | B=18-66 |
| 6JZC | X-ray | 2.2 Å | C/D=1-66 |
| 6J8F | X-ray | 2.28 Å | A=3-48 |
| 6K81 | X-ray | 2.28 Å | B=1-66 |
| 6J4O | X-ray | 2.3 Å | B=1-66 |
| 6LPG | X-ray | 2.3 Å | B=2-66 |
| 6J9H | X-ray | 2.31 Å | A/C=1-66 |
| 6JZD | X-ray | 2.48 Å | B=1-66 |
| 6JZE | X-ray | 2.51 Å | B=1-66 |
| 6J4Q | X-ray | 2.7 Å | B/D/G/K=1-66 |
Showing 20 of 24 experimental structures (best resolution first).
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