Nucleoporin NUP35 (NUP35) is a 326-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8NFH5.
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The mean pLDDT of this model is 63.2 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 22% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 37% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC
Interacts with TMEM48/NDC1. Forms a complex with NUP93, NUP155, NUP205 and lamin B; the interaction with NUP93 is direct
Nucleus, nuclear pore complex, Nucleus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8OZB | X-ray | 2.09 Å | E/F=173-248 |
| 4LIR | X-ray | 2.46 Å | A/B=151-266 |
| 7MW1 | X-ray | 3.4 Å | C/D=84-150 |
| 7R5K | EM | 12.0 Å | F0/F1/F2/F3=1-326 |
| 7R5J | EM | 50.0 Å | F0/F1/F2/F3=1-326 |
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