Muscarinic toxin 7 is a 86-residue protein from Dendroaspis angusticeps. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8QGR0.
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The mean pLDDT of this model is 90.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 70% |
| 70 to 90 | Confident: backbone generally right | 27% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Binds specifically and irreversibly to an allosteric site of the muscarinic acetylcholine M1 receptor (CHRM1) at subnanomolar concentrations and shows a very slow dissociation rate (PubMed:10799315, PubMed:11562434, PubMed:12488533, PubMed:21557730). It also inhibits agonist-mediated guanosine 5'-O-(3'-thiotriphosphate) (GTP-g-S) binding and downstream signaling, and decreases the dissociation rate of orthosteric antagonists (N-methylscopolamine (NMS) or pirenzepine) (PubMed:10799315, PubMed:15033377). Is a potent negative allosteric modulator (NAM) for CHRM1 activation and a positive allosteric modulator (PAM) for antagonist binding (Probable)
Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3NEQ | X-ray | 1.25 Å | A/B=22-69, A/B=80-86 |
| 3FEV | X-ray | 1.3 Å | A/B/C=38-86 |
| 2VLW | X-ray | 1.39 Å | A/B=22-86 |
| 6WJC | X-ray | 2.55 Å | C=22-86 |
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