Charged multivesicular body protein 4 (shrb) is a 226-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8T0Q4.
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The mean pLDDT of this model is 78.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 16% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Probable core polymerization component of the endosomal sorting required for transport (ESCRT) III complex involved in multiple cellular processes requiring the outward bending of membranes, including vesicle budding, membrane repair and cytokinesis (Probable). The ESCRT pathway involves 4 complexes (ESCRT-0, -I, -II and -III) that sequentially assemble on the cytoplasmic side of membranes and induce membrane remodeling, budding and scission. As part of the ESCRT-III complex, involved in the budding of intraluminal vesicles (ILVs) into endosomes to form multivesicular bodies (MVBs), which target their contents for degradation via the endolysosomal pathway (PubMed:16713958). Involved in…
Homopolymer; forms elongated striated filaments of uniform ~10nm width (PubMed:27452459). Monomers interact in a staggered arrangement mediated by complementary charged electrostatic surfaces (PubMed:27452459). Interacts with l(2)gd1 (via DM14 domains 1 and 3); the interaction is direct and blocks access to the surface involved in homopolymerization (PubMed:22389409, PubMed:27452459,…
Endosome, Endosome, multivesicular body, Midbody
Compare the prediction with experimentally determined structures of the same protein:
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