Gasdermin-B (GSDMB) is a 416-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TAX9.
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The mean pLDDT of this model is 71.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Precursor of a pore-forming protein that acts as a downstream mediator of granzyme-mediated cell death (PubMed:32299851). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-B, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:32299851). Also acts as a regulator of epithelial cell repair independently of programmed cell death: translocates to the plasma membrane and promotes epithelial maintenance and repair by regulating PTK2/FAK-mediated phosphorylation of PDGFA (PubMed:35021065)
Homooligomer; homooligomeric ring-shaped pore complex containing 24-26 subunits when inserted in the membrane
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5TIB | X-ray | 2.6 Å | A/B=216-411 |
| 9K1S | X-ray | 2.69 Å | C/D=245-416 |
| 7WJQ | X-ray | 2.7 Å | B=1-411 |
| 8GTJ | X-ray | 2.7 Å | A/C=1-416 |
| 5TJ2 | X-ray | 2.8 Å | A/B/C/D=216-411 |
| 8GTK | X-ray | 3.1 Å | A=1-416 |
| 8GTN | EM | 3.17 Å | A/AA/B/BA/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y/Z=1-235 |
| 5TJ4 | X-ray | 3.5 Å | A/B/C/D/E/F/G/H/I/J=217-415 |
| 8EFP | EM | 3.8 Å | C=1-416 |
| 8ET1 | EM | 4.48 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-416 |
| 8ET2 | EM | 4.96 Å | A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-416 |
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