Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) is a 1659-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8TCU6.
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The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 42% |
| 70 to 90 | Confident: backbone generally right | 36% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils
Interacts preferentially with RAC2. Interacts with RAC1. Interacts with AUTS2
Cytoplasm, cytosol, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5D3X | X-ray | 1.69 Å | A/B=245-408 |
| 5D3V | X-ray | 1.85 Å | A/B=245-408 |
| 5D3W | X-ray | 1.85 Å | A/B=245-408 |
| 5D27 | X-ray | 1.92 Å | A=245-408 |
| 4YON | X-ray | 1.95 Å | A=1-404 |
| 5D3Y | X-ray | 1.95 Å | A/B=245-408 |
| 3QIK | X-ray | 2.28 Å | A=607-706 |
| 6VSK | X-ray | 3.12 Å | A=409-499 |
| 5FI1 | X-ray | 3.2 Å | A=38-408 |
| 6PCV | EM | 3.2 Å | A=38-1659 |
| 7RX9 | X-ray | 3.22 Å | A=41-305, A=323-502 |
| 5FI0 | X-ray | 3.28 Å | A/C/E/G=38-408 |
| 8TUA | EM | 4.1 Å | A=35-1659 |
| 7SYF | EM | 4.2 Å | A=41-305, A=323-1117, A=1119-1659 |
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