Cytoglobin (CYGB) is a 190-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q8WWM9.
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The mean pLDDT of this model is 87.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 76% |
| 70 to 90 | Confident: backbone generally right | 7% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:11893755, PubMed:12359339, PubMed:15165856, PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819, PubMed:29128400, PubMed:33576020, PubMed:34930834). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and…
Monomeric (PubMed:20553503). Homodimer; disulfide-linked in vitro (PubMed:15044115, PubMed:15165856, PubMed:16699195). Also homooligomeric in vitro (PubMed:15165856)
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2DC3 | X-ray | 1.68 Å | A/B=1-190 |
| 1URV | X-ray | 2.0 Å | A/B=1-190 |
| 1UT0 | X-ray | 2.1 Å | A/B=1-190 |
| 1URY | X-ray | 2.4 Å | A/B=1-190 |
| 1UX9 | X-ray | 2.4 Å | A/B=1-190 |
| 1V5H | X-ray | 2.4 Å | A=1-190 |
| 1UMO | X-ray | 2.59 Å | A/B=1-190 |
| 3AG0 | X-ray | 2.6 Å | A=1-190 |
| 4B3W | X-ray | 2.8 Å | A/B=1-190 |
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