Hamartin (TSC1) is a 1164-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92574.
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The mean pLDDT of this model is 62.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 25% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 10% |
| Below 50 | Very low: often disordered regions | 43% |
What pLDDT means and how to read it
Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12906785, PubMed:15340059, PubMed:24529379, PubMed:28215400). The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12906785, PubMed:15340059, PubMed:24529379). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing…
Component of the TSC-TBC complex (also named Rhebulator complex), composed of 2 molecules of TSC1, 2 molecules of TSC2 and 1 molecule of TBC1D7 (PubMed:10585443, PubMed:12172553, PubMed:12906785, PubMed:15963462, PubMed:16464865, PubMed:17658474, PubMed:22795129, PubMed:24529379, PubMed:26893383, PubMed:28215400, PubMed:33215753, PubMed:33436626, PubMed:9580671, PubMed:9809973). Probably forms a…
Lysosome membrane, Cytoplasm, cytosol
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4Z6Y | X-ray | 2.81 Å | C/D/F/H=938-993 |
| 9CE3 | EM | 2.9 Å | C/D=1-1164 |
| 5EJC | X-ray | 3.1 Å | C/D/E/F=939-992 |
| 9C9I | X-ray | 3.18 Å | B/D/F/H/X=648-681 |
| 7DL2 | EM | 4.4 Å | C/D=1-1164 |
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