Sortilin-related receptor (SORL1) is a 2214-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q92673.
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The mean pLDDT of this model is 73.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 15% |
| 70 to 90 | Confident: backbone generally right | 52% |
| 50 to 70 | Low: treat with caution | 22% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting (PubMed:17646382). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (PubMed:16174740, PubMed:16407538, PubMed:17855360, PubMed:24523320). May also sort newly produced amyloid-beta peptides to lysosomes for catabolism (PubMed:24523320). Does not affect APP trafficking from the endoplasmic reticulum to Golgi…
After maturation cleavage, interacts (via N-terminus) with its own propeptide; this interaction prevents interaction with other ligands, including CRLF1, GDNF, GFRA1, IL6 and IL6R (PubMed:11294867, PubMed:12530537, PubMed:15364913, PubMed:23333276, PubMed:24523320). Interacts (via N-terminal ectodomain) with APP, forming a 1:1 stoichiometric complex, including with isoforms APP695, APP751 and…
Golgi apparatus membrane, Golgi apparatus, trans-Golgi network membrane, Endosome membrane, Early endosome membrane, Recycling endosome membrane, Endoplasmic reticulum membrane, Endosome, multivesicular body membrane, Cell membrane, Cytoplasmic vesicle, secretory vesicle membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3G2S | X-ray | 1.7 Å | C/D=2202-2214 |
| 3G2T | X-ray | 2.0 Å | C/D=2202-2214 |
| 3WSX | X-ray | 2.35 Å | A=29-753 |
| 3WSY | X-ray | 3.11 Å | A=86-753, C=42-56 |
| 3WSZ | X-ray | 3.2 Å | A=86-753 |
| 7VT0 | EM | 3.4 Å | A/B=89-752 |
| 2DM4 | NMR | A=1651-1745 |
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